Thr156

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Phosphorylation Site Page:

Site Information

SQITSQVtGQIGWRR SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: AP2M1 (human): T156, AP2M1 (mouse): T156, AP2M1 iso2 (human): T154

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	mutation of modification site (2)
Relevant cell line - cell type - tissue:	HeLa (cervical) [AP2M1 (rat)] (2)

Downstream Regulation

Effects of modification on AP2M1:	intracellular localization (2), molecular association, regulation (1), protein conformation (1)
Induce interaction with:	TGOLN2 (human) (1)

	References

1	Höning S, et al. (2005) Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2. Mol Cell 18, 519-31 15916959 Curated Info
2	Olusanya O, Andrews PD, Swedlow JR, Smythe E (2001) Phosphorylation of threonine 156 of the mu2 subunit of the AP2 complex is essential for endocytosis in vitro and in vivo. Curr Biol 11, 896-900 11516654 Curated Info

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