Ser686
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Phosphorylation Site Page:
Ser686 - CD44 (human)

Site Information
KKKLVINsGNGAVED    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: CD44 (mouse): G722, CD44 (rat): S447, CD44 iso2 (mouse): G307, CD44 iso30 (human): S686
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (2, 3, 4, 5, 6, 7, 8)
Disease tissue studied: cervical cancer (5), cervical adenocarcinoma (5)
Relevant cell line - cell type - tissue: A498 (renal) (4), GM00130 (B lymphocyte) (3), HeLa (cervical) (2, 6, 8), HeLa S3 (cervical) (5), TERT20 ('stem, mesenchymal') (7)

Controlled by
Treatments: ionizing radiation (3), nocodazole (5)



References

1

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

2

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

3

Bennetzen MV, et al. (2010) Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response. Mol Cell Proteomics 9, 1314-23
20164059   Curated Info

4

Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62
20071362   Curated Info

5

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

6

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

7

Thingholm TE, et al. (2008) TiO2-Based Phosphoproteomic Analysis of the Plasma Membrane and the Effects of Phosphatase Inhibitor Treatment. J Proteome Res 7, 3304-3313
18578522   Curated Info

8

Olsen JV, et al. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 127, 635-48
17081983   Curated Info

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