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| Phosphorylation Site Page: |
| Ser235 - S6 (rat) |  |
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References | |
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Srivastava T, et al. (2012) Regulation of neuronal mRNA translation by CaM-kinase I phosphorylation of eIF4GII. J Neurosci 32, 5620-30
22514323 Curated Info |
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Van de Velde S, Hogan MF, Montminy M (2011) mTOR links incretin signaling to HIF induction in pancreatic beta cells. Proc Natl Acad Sci U S A 108, 16876-82
21949366 Curated Info |
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Demirkan G, et al. (2011) Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1). PLoS One 6, e21729
21738781 Curated Info |
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Wu M, et al. (2010) Acetaminophen improves protein translational signaling in aged skeletal muscle. Rejuvenation Res 13, 571-9
20818934 Curated Info |
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Blancquaert S, et al. (2010) cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4. Mol Endocrinol 24, 1453-68
20484410 Curated Info |
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Short JD, et al. (2010) AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Mol Carcinog 49, 429-39
20146253 Curated Info |
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(2009) CST Curation Set: 6823; Year: 2009; Biosample: PC-12; Disease: pheochromocytoma; Treatment: forskolin; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-RRX(s/t)(phosphorylation) Antibody Used to Purify Peptides prior to MS2: Phospho-PKA Substrate (RRXS/T) (100G7) Rabbit mAb Cat#: 9624, PTMScan(R) Phospho-PKA Substrate Motif (K/RK/RXS*/T*) Immunoaffinity Beads Cat#: 1984
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(2009) CST Curation Set: 6822; Year: 2009; Biosample: PC-12; Disease: pheochromocytoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-RRX(s/t)(phosphorylation) Antibody Used to Purify Peptides prior to MS2: Phospho-PKA Substrate (RRXS/T) (100G7) Rabbit mAb Cat#: 9624, PTMScan(R) Phospho-PKA Substrate Motif (K/RK/RXS*/T*) Immunoaffinity Beads Cat#: 1984
Curated Info |
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(2009) CST Curation Set: 6821; Year: 2009; Biosample: PC-12; Disease: pheochromocytoma; Treatment: forskolin; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-RRX(s/t)(phosphorylation) Antibody Used to Purify Peptides prior to MS2: Phospho-PKA Substrate (RRXS/T) (100G7) Rabbit mAb Cat#: 9624, PTMScan(R) Phospho-PKA Substrate Motif (K/RK/RXS*/T*) Immunoaffinity Beads Cat#: 1984
Curated Info |
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(2009) CST Curation Set: 6820; Year: 2009; Biosample: PC-12; Disease: pheochromocytoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-RRX(s/t)(phosphorylation) Antibody Used to Purify Peptides prior to MS2: Phospho-PKA Substrate (RRXS/T) (100G7) Rabbit mAb Cat#: 9624, PTMScan(R) Phospho-PKA Substrate Motif (K/RK/RXS*/T*) Immunoaffinity Beads Cat#: 1984
Curated Info |
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Hou Z, He L, Qi RZ (2007) Regulation of s6 kinase 1 activation by phosphorylation at ser-411. J Biol Chem 282, 6922-8
17220300 Curated Info |
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Noga AA, et al. (2007) Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophy. Am J Physiol Heart Circ Physiol 292, H1460-9
17098823 Curated Info |
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Lang CH (2006) Elevated plasma free fatty acids decrease basal protein synthesis, but not the anabolic effect of leucine, in skeletal muscle. Am J Physiol Endocrinol Metab 291, E666-74
16684854 Curated Info |
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Thomson DM, Gordon SE (2006) Impaired overload-induced muscle growth is associated with diminished translational signalling in aged rat fast-twitch skeletal muscle. J Physiol 574, 291-305
16627569 Curated Info |
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Hong-Brown LQ, et al. (2005) Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle. Am J Physiol Endocrinol Metab 289, E382-90
15827064 Curated Info |
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Lécureuil C, et al. (2005) Follicle-stimulating hormone activates p70 ribosomal protein S6 kinase by protein kinase A-mediated dephosphorylation of Thr 421/Ser 424 in primary Sertoli cells. Mol Endocrinol 19, 1812-20
15774499 Curated Info |
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Kubica N, et al. (2005) Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bepsilon mRNA in a mammalian target of rapamycin-dependent manner. J Biol Chem 280, 7570-80
15591312 Curated Info |
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Chiu T, Santiskulvong C, Rozengurt E (2005) EGF receptor transactivation mediates ANG II-stimulated mitogenesis in intestinal epithelial cells through the PI3-kinase/Akt/mTOR/p70S6K1 signaling pathway. Am J Physiol Gastrointest Liver Physiol 288, G182-94
15358595 Curated Info |
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Adachi H, et al. (2004) Niban gene is commonly expressed in the renal tumors: a new candidate marker for renal carcinogenesis. Oncogene 23, 3495-500
14990989 Curated Info |
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Bolster DR, et al. (2003) Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle. J Physiol 553, 213-20
12937293 Curated Info |
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Kumar V, Frost RA, Lang CH (2002) Alcohol impairs insulin and IGF-I stimulation of S6K1 but not 4E-BP1 in skeletal muscle. Am J Physiol Endocrinol Metab 283, E917-28
12376318 Curated Info |
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Wang X, et al. (2002) Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin. Biochem J 367, 475-81
12133000 Curated Info |
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Flotow H, Thomas G (1992) Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver. J Biol Chem 267, 3074-8
1737763 Curated Info |
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Ferrari S, et al. (1991) Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites. J Biol Chem 266, 22770-5
1939282 Curated Info |
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Krieg J, Hofsteenge J, Thomas G (1988) Identification of the 40 S ribosomal protein S6 phosphorylation sites induced by cycloheximide. J Biol Chem 263, 11473-7
3403539 Curated Info |
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Wettenhall RE, Morgan FJ (1984) Phosphorylation of hepatic ribosomal protein S6 on 80 and 40 S ribosomes. Primary structure of S6 in the region of the major phosphorylation sites for cAMP-dependent protein kinases. J Biol Chem 259, 2084-91
6698958 Curated Info |
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