Ser178

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Phosphorylation Site Page:

Site Information

SDRRSVAsSQPAKPT SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: ZO1 (human): S178, ZO1 (rat): S166, ZO1 iso2 (human): S178, ZO1 iso2 (mouse): S178

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	mass spectrometry (1, 2, 3, 4, 5, 6)
Disease tissue studied:	melanoma skin cancer (5)
Relevant cell line - cell type - tissue:	brain (1, 3, 4), kidney (3), liver (3, 6), lung (3), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (2), skin [mGluR1 (mouse), transgenic, TG mutant mice] (5), spleen (3), testis (3)

	References

1	Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9 22807455 Curated Info
2	Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6 21659605 Curated Info
3	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info
4	Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9 20415495 Curated Info
5	Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26 19367708 Curated Info
6	Villén J, Beausoleil SA, Gerber SA, Gygi SP (2007) Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A 104, 1488-93 17242355 Curated Info

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