Ser297

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Phosphorylation Site Page:

Site Information

GTPVHCPsPIRVHTV SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: BAG3 (human): S291, BAG3 (rat): S294

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	mass spectrometry (1, 2, 3, 4, 5, 6, 7)
Relevant cell line - cell type - tissue:	'fat, brown'-'fat, brown' (5), 3T3 (fibroblast) (6), brain (2), heart (5), kidney (5), liver (7), lung (5), MEF (fibroblast) (1, 4), MEF (fibroblast) [p53 (mouse), homozygous knockout] (3), MEF (fibroblast) [raptor (mouse), knockdown] (1), MEF (fibroblast) [rictor (mouse), knockdown] (1), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (4), spleen (5)

Controlled by

Regulatory protein:	raptor (mouse) (1), rictor (mouse) (1)
Treatments:	NAG-thiazoline (6), PUGNAc (6)

	References

1	Robitaille AM, et al. (2013) Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339, 1320-3 23429704 Curated Info
2	Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29 22645316 Curated Info
3	Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22 21659604 Curated Info
4	Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6 21659605 Curated Info
5	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info
6	Wang Z, Gucek M, Hart GW (2008) Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc. Proc Natl Acad Sci U S A 105, 13793-8 18779572 Curated Info
7	Villén J, Beausoleil SA, Gerber SA, Gygi SP (2007) Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A 104, 1488-93 17242355 Curated Info

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