Ser297
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Phosphorylation Site Page:
Ser297 - BAG3 (mouse)

Site Information
GTPVHCPsPIRVHTV    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: BAG3 (human): S291, BAG3 (rat): S294
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 467532

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (2), 'fat, brown'-'fat, brown' (10), 3T3 (fibroblast) (11), brain (7), heart (3, 10), kidney (10), liver (1, 6, 12), lung (10), macrophage-peritoneum (5), MEF (fibroblast) (4, 9), MEF (fibroblast) [p53 (mouse), homozygous knockout] (8), MEF (fibroblast) [Raptor (mouse), knockdown] (4), MEF (fibroblast) [RICTOR (mouse), knockdown] (4), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (9), spleen (10)

Controlled by
Regulatory protein: Raptor (mouse) (4), RICTOR (mouse) (4)
Treatments: insulin (2), LY294002 (2), MK-2206 (2), NAG-thiazoline (11), PUGNAc (11)



References

1

Wilson-Grady JT, Haas W, Gygi SP (2013) Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation. Methods 61, 277-86
23567750   Curated Info

2

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

3

Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11
23737553   Curated Info

4

Robitaille AM, et al. (2013) Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339, 1320-3
23429704   Curated Info

5

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

6

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

7

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

8

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

9

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

10

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

11

Wang Z, Gucek M, Hart GW (2008) Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc. Proc Natl Acad Sci U S A 105, 13793-8
18779572   Curated Info

12

Villén J, Beausoleil SA, Gerber SA, Gygi SP (2007) Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A 104, 1488-93
17242355   Curated Info

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