Tyr573

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Phosphorylation Site Page:

Tyr573 - Kit (mouse)

Site Information

INGNNYVyIDPTQLP SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: Kit (human): Y570

Blast this site against: NCBI SwissProt PDB

Available spectra: 1 CST

In vivo Characterization

Methods used to characterize site in vivo:	mass spectrometry (3, 4, 5, 6), mutation of modification site (1), phospho-antibody (1, 2), western blotting (1, 2)
Relevant cell line - cell type - tissue:	BaF3 ('B lymphocyte, precursor') (1), BMMC (mast) (1), mast-bone marrow (3), mast-bone marrow [PTPRA (mouse), homozygous knockout] (2)

Controlled by

Regulatory protein:	FcER1A (mouse) (3)
Treatments:	SCF (1, 2), SU6656 (2)

	References

1	Simon C, et al. (2008) Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells. Blood 112, 4039-47 18753636 Curated Info
2	Samayawardhena LA, Pallen CJ (2008) Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells. J Biol Chem 283, 29175-85 18725415 Curated Info
3	Cao L, et al. (2007) Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. J Immunol 179, 5864-76 17947660 Curated Info
4	(2006) CST Curation Set: 1517; Year: 2006; Biosample: Thom; Disease: -; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
5	(2006) CST Curation Set: 1518; Year: 2006; Biosample: Thom; Disease: -; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
6	(2006) CST Curation Set: 1519; Year: 2006; Biosample: Thom; Disease: -; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info

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