Tyr573
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Phosphorylation Site Page:
Tyr573 - Kit (mouse)

Site Information
INGNNYVyIDPTQLP    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: Kit (human): Y570, Kit (rat): Y572
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448015
Available spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (3, 4, 5, 6), mutation of modification site (1), phospho-antibody (1, 2), western blotting (1, 2)
Relevant cell line - cell type - tissue: BaF3 ('B lymphocyte, precursor') (1), BMMC (mast) (1), mast-bone marrow (3), mast-bone marrow [PTPRA (mouse), homozygous knockout] (2)

Controlled by
Regulatory protein: FcER1A (mouse) (3)
Treatments: SCF (1, 2), SU6656 (2)



References

1

Simon C, et al. (2008) Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells. Blood 112, 4039-47
18753636   Curated Info

2

Samayawardhena LA, Pallen CJ (2008) Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells. J Biol Chem 283, 29175-85
18725415   Curated Info

3

Cao L, et al. (2007) Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. J Immunol 179, 5864-76
17947660   Curated Info

4

(2006) CST Curation Set: 1517; Year: 2006; Biosample/Treatment: cell line, Thom/serum starved; Disease: -; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

5

(2006) CST Curation Set: 1518; Year: 2006; Biosample/Treatment: cell line, Thom/untreated; Disease: -; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

6

(2006) CST Curation Set: 1519; Year: 2006; Biosample/Treatment: cell line, Thom/untreated; Disease: -; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

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