Tyr571
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Phosphorylation Site Page:
Tyr571 - Kit (mouse)

Site Information
EEINGNNyVYIDPTQ    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: Kit (human): Y568
Blast this site against: NCBI  SwissProt  PDB 
Available spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (4, 6, 7), mutation of modification site (2, 5, 8), phospho-antibody (2, 3), western blotting (2, 3)
Relevant cell line - cell type - tissue: BaF3 ('B lymphocyte, precursor') (2, 5, 8), BMMC (mast) (2), COS (fibroblast) (8), mast-bone marrow (4, 5), mast-bone marrow [PTPRA (mouse), homozygous knockout] (3), MEF (fibroblast) [IGF1R (mouse)] (8)

Controlled by
Regulatory protein: FcER1A (mouse) (4)
Treatments: SCF (2, 3, 5, 8), SU6656 (3)

Downstream Regulation
Effects of modification on Kit: activity, induced (2), molecular association, regulation (2, 5, 8)
Effects of modification on biological processes: cell growth, altered (2), cell motility, altered (2)
Induce interaction with: Gab2 (mouse) (5), LNK (mouse) (2), SHP-2 (mouse) (5), SOCS6 (mouse) (8), Shc1 (mouse) (5)


References

1

(2010) CST Curation Set: 9108; Year: 2010; Biosample/Treatment: cell line, PY2/untreated; Disease: -; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-102) Cat#: 9416
Curated Info

2

Simon C, et al. (2008) Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells. Blood 112, 4039-47
18753636   Curated Info

3

Samayawardhena LA, Pallen CJ (2008) Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells. J Biol Chem 283, 29175-85
18725415   Curated Info

4

Cao L, et al. (2007) Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. J Immunol 179, 5864-76
17947660   Curated Info

5

Yu M, et al. (2006) The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway. J Biol Chem 281, 28615-26
16873377   Curated Info

6

(2006) CST Curation Set: 1518; Year: 2006; Biosample/Treatment: cell line, Thom/untreated; Disease: -; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

7

(2006) CST Curation Set: 1519; Year: 2006; Biosample/Treatment: cell line, Thom/untreated; Disease: -; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

8

Bayle J, et al. (2004) Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling. J Biol Chem 279, 12249-59
14707129   Curated Info

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