Tyr989

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Phosphorylation Site Page:

Site Information

YASSNPEyLSASDVF SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: InsR (human): Y999, InsR (rat): Y1000, InsR iso2 (human): Y987

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	phospho-antibody (1, 2), western blotting (2)
Relevant cell line - cell type - tissue:	liver (1), MEF (fibroblast) [IGF1R (mouse)] (2)

Controlled by

Putative upstream phosphatases:	PTP1B (mouse) (1)
Treatments:	insulin (1, 2), siRNA (2)

	References

1	Haj FG, et al. (2005) Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice. J Biol Chem 280, 15038-46 15699041 Curated Info
2	Galic S, et al. (2005) Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP. Mol Cell Biol 25, 819-29 15632081 Curated Info

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