Tyr989
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Phosphorylation Site Page:
Tyr989 - InsR (mouse)

Site Information
YASSNPEyLSASDVF    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: InsR (human): Y999, InsR (rat): Y1000, InsR iso2 (human): Y987
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: phospho-antibody (1, 2), western blotting (2)
Relevant cell line - cell type - tissue: liver (1), MEF (fibroblast) [IGF1R (mouse)] (2)

Controlled by
Putative upstream phosphatases: PTP1B (mouse) (1)
Treatments: insulin (1, 2), siRNA (2)



References

1

Haj FG, et al. (2005) Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice. J Biol Chem 280, 15038-46
15699041   Curated Info

2

Galic S, et al. (2005) Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP. Mol Cell Biol 25, 819-29
15632081   Curated Info

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