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Phosphorylation Site Page:
Ser733 - CD44 (mouse)

Site Information
TVEDRKPsELNGEAS    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: CD44 (human): S697, CD44 (rat): S458, CD44 iso2 (mouse): S318, CD44 iso30 (human): S697, CD44 iso12 (human): S316, CD44 iso10 (human): S448
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 465669

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
Disease tissue studied: anthrax infection (8), leukemia (6), acute myelogenous leukemia (6), melanoma skin cancer (12)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (3), 3T3 (fibroblast) [CDC42 (human), transfection] (2), blood (6), Hepa 1-6 (epithelial) (13), liver (5), liver [leptin (mouse), homozygous knockout] (5), lung (9), macrophage-bone marrow (10), macrophage-bone marrow [MKP-1 (mouse), homozygous knockout] (10), macrophage-peritoneum [RIP3 (mouse), homozygous knockout] (4), MC3T3-E1 (preosteoblast) (1), MEF (fibroblast) [p53 (mouse), homozygous knockout] (7), RAW 267.4 (macrophage) (11), skin [mGluR1 (mouse), transgenic, TG mutant mice] (12), spleen (8, 9)

Controlled by
Regulatory protein: CDC42 (mouse) (2), KRas (mouse) (2), PAK4 (mouse) (2)
Treatments: insulin (3), LPS (10), LY294002 (3), PTH(1-34) (1)



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Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
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Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
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Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
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Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
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Trost M, et al. (2009) The phagosomal proteome in interferon-gamma-activated macrophages. Immunity 30, 143-54
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Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
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Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46
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