Ser733
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Phosphorylation Site Page:
Ser733 - CD44 (mouse)

Site Information
TVEDRKPsELNGEAS    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: CD44 (human): S697, CD44 (rat): S458, CD44 iso10 (human): S448, CD44 iso12 (human): S316, CD44 iso30 (human): S697, CD44 iso2 (mouse): S318
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 465669

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
Disease tissue studied: anthrax infection (7), leukemia (5), acute myelogenous leukemia (5), melanoma skin cancer (11)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (2), 3T3 (fibroblast) [CDC42 (human), transfection] (1), blood (5), Hepa 1-6 (epithelial) (12), liver (4), liver [leptin (mouse), homozygous knockout] (4), lung (8), macrophage-bone marrow (9), macrophage-bone marrow [MKP-1 (mouse), homozygous knockout] (9), macrophage-peritoneum [RIP3 (mouse), homozygous knockout] (3), MEF (fibroblast) [p53 (mouse), homozygous knockout] (6), RAW 267.4 (macrophage) (10), skin [mGluR1 (mouse), transgenic, TG mutant mice] (11), spleen (7, 8)

Controlled by
Regulatory protein: CDC42 (mouse) (1), KRas (mouse) (1), PAK4 (mouse) (1)
Treatments: insulin (2), LPS (9), LY294002 (2)



References

1

Gnad F, et al. (2013) Systems-wide Analysis of K-Ras, Cdc42, and PAK4 Signaling by Quantitative Phosphoproteomics. Mol Cell Proteomics 12, 2070-80
23608596   Curated Info

2

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

3

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

4

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

5

Trost M, et al. (2012) Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, e17-27
22802335   Curated Info

6

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

7

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

8

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

9

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

10

Trost M, et al. (2009) The phagosomal proteome in interferon-gamma-activated macrophages. Immunity 30, 143-54
19144319   Curated Info

11

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

12

Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46
18846507   Curated Info

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