Lys10
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Acetylation Site Page:
Lys10 - H3 (rat)

Site Information
RTKQTARkSTGGKAP    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: H3 (human): K10, H3 (chicken): K10, H3 (mouse): K10, H3 iso3 (rat): K10, H3 (cow): K10, H3 (pig): K10, H3 iso3 (mouse): K10, H3 iso2 (mouse): K10
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: immunoprecipitation (5), phospho-antibody (5, 6)
Disease tissue studied: liver cancer (5), hepatocellular carcinoma (5)
Relevant cell line - cell type - tissue: HL1C (hepatocyte) (5), RAEC (endothelial) (6)

Controlled by
Treatments: glucose (5), oxysterol (6)



References

1

James TT, Aroor AR, Lim RW, Shukla SD (2012) Histone H3 phosphorylation (Ser10, Ser28) and phosphoacetylation (K9S10) are differentially associated with gene expression in liver of rats treated in vivo with acute ethanol. J Pharmacol Exp Ther 340, 237-47
22025646   Curated Info

2

Aroor AR, James TT, Jackson DE, Shukla SD (2010) Differential changes in MAP kinases, histone modifications, and liver injury in rats acutely treated with ethanol. Alcohol Clin Exp Res 34, 1543-51
20586759   Curated Info

3

Kawakami K, et al. (2009) Age-related difference of site-specific histone modifications in rat liver. Biogerontology 10, 415-21
18814051   Curated Info

4

Tian F, et al. (2009) Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor-mediated activation of Bdnf gene promoter 1. J Neurochem 109, 1375-88
19476549   Curated Info

5

Eckert DT, et al. (2008) Detailed molecular analysis of the induction of the L-PK gene by glucose. Biochem Biophys Res Commun 372, 131-6
18468514   Curated Info

6

Romeo GR, Kazlauskas A (2008) Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. J Biol Chem 283, 9595-605
18230613   Curated Info

7

Tang CH, et al. (2007) Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia. J Immunol 179, 1292-302
17617622   Curated Info

8

Sahar S, et al. (2007) Cooperation of SRC-1 and p300 with NF-kappaB and CREB in angiotensin II-induced IL-6 expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 27, 1528-34
17495236   Curated Info

9

Park PH, Lim RW, Shukla SD (2005) Involvement of histone acetyltransferase (HAT) in ethanol-induced acetylation of histone H3 in hepatocytes: potential mechanism for gene expression. Am J Physiol Gastrointest Liver Physiol 289, G1124-36
16081763   Curated Info

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