Ser37
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Phosphorylation Site Page:
Ser37 - CTNNB1 (mouse)

Site Information
YLDSGIHsGATTTAP    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: CTNNB1 (human): S37, CTNNB1 (rat): S37
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447582

In vivo Characterization
Methods used to characterize site in vivo: immunoprecipitation (15), mutation of modification site (6, 12, 15), phospho-antibody (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 13), western blotting (1, 4, 5, 6, 7, 8, 9, 10, 11, 15)
Disease tissue studied: leukemia (2), acute myelogenous leukemia (2), neuroblastoma (15)
Relevant cell line - cell type - tissue: 'brain, striatum' (13), 'neuron, cortical'-brain (4), 'neuron, hippocampal'-brain (4), 293 (epithelial) (6), 293T (epithelial) (5), brain (7), brain [CDK5R1 (mouse)] (7), E14tg2a ('stem, embryonic') (11), epithelial [PIK3R1 (mouse), homozygous knockout] (3), intestine [CK1A (mouse), homozygous knockout] (1), L cells (fibroblast) (9, 10), MEF (fibroblast) [JNK1 (mouse), transfection] (6), Neuro-2A (neuron) (15), stem (2), Swiss 3T3 (fibroblast) (12), uterus (8)

Controlled by
Regulatory protein: CDK5R1 (mouse) (7), CK1A (mouse) (1), DISC1 (human) (4), DISC1 (mouse) (4), Huntingtin (mouse) (13), PIK3R1 (mouse) (3), ZBED3 (mouse) (5)
Putative upstream kinases: GSK3B (human) (5, 15)
Kinases, in vitro: GSK3B (mouse) (14)
Treatments: LIF (11), LLnL (15), LY294002 (11), MG132 (9), QLT0267 (10), siRNA (4), Wnt3a (10)

Downstream Regulation
Effects of modification on CTNNB1: protein degradation (12, 15), ubiquitination (15)

Disease / Diagnostics Relevance
Relevant diseases: acute myelogenous leukemia (2)

References

1

Elyada E, et al. (2011) CKIα ablation highlights a critical role for p53 in invasiveness control. Nature 470, 409-13
21331045   Curated Info

2

Yeung J, et al. (2010) β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells. Cancer Cell 18, 606-18
21156284   Curated Info

3

Lee G, et al. (2010) Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology 139, 869-81, 881.e1-9
20580720   Curated Info

4

Mao Y, et al. (2009) Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 136, 1017-31
19303846   Curated Info

5

Chen T, et al. (2009) Identification of Zinc-finger BED Domain-containing 3 (Zbed3) as a Novel Axin-interacting Protein That Activates Wnt/{beta}-Catenin Signaling. J Biol Chem 284, 6683-9
19141611   Curated Info

6

Hu D, et al. (2008) c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway. Carcinogenesis 29, 2317-24
18952597   Curated Info

7

Wen Y, et al. (2008) Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. J Neurosci 28, 2624-32
18322105   Curated Info

8

Herington JL, Bi J, Martin JD, Bany BM (2007) Beta-catenin (CTNNB1) in the mouse uterus during decidualization and the potential role of two pathways in regulating its degradation. J Histochem Cytochem 55, 963-74
17533218   Curated Info

9

Abe K, Takeichi M (2007) NMDA-receptor activation induces calpain-mediated beta-catenin cleavages for triggering gene expression. Neuron 53, 387-97
17270735   Curated Info

10

Oloumi A, Syam S, Dedhar S (2006) Modulation of Wnt3a-mediated nuclear beta-catenin accumulation and activation by integrin-linked kinase in mammalian cells. Oncogene 25, 7747-57
16799642   Curated Info

11

Paling NR, Wheadon H, Bone HK, Welham MJ (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J Biol Chem 279, 48063-70
15328362   Curated Info

12

Liu J, Farmer SR (2004) Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylation-defective mutant of beta-catenin inhibits expression of a subset of adipogenic genes. J Biol Chem 279, 45020-7
15308623   Curated Info

13

Gines S, et al. (2003) Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells. J Biol Chem 278, 50514-22
14522959   Curated Info

14

Sakanaka C (2002) Phosphorylation and regulation of beta-catenin by casein kinase I epsilon. J Biochem (Tokyo) 132, 697-703
12417018   Curated Info

15

Aberle H, et al. (1997) beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16, 3797-804
9233789   Curated Info

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