Ser362
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Phosphorylation Site Page:
Ser362 - Fos (mouse)

Site Information
AAAHRKGsSSNEPSS    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: Fos (rat): S362, Fos (human): S362
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: immunoprecipitation (1), mutation of modification site (1, 3), phospho-antibody (1, 3), western blotting (1)
Relevant cell line - cell type - tissue: 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] (3), bone (3), BV2 (microglia) (1), monocyte (3)

Controlled by
Putative upstream kinases: PKACA (mouse) (1), RSK2 (mouse) (3)
Treatments: LPS (1), M-CSF (3), MG132 (3)

Downstream Regulation
Effects of modification on Fos: molecular association, regulation (1), protein stabilization (3)
Induce interaction with: ER-beta (mouse) (1)


References

1

Saijo K, et al. (2011) An ADIOL-ERĪ²-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Cell 145, 584-95
21565615   Curated Info

2

Bakiri L, et al. (2011) Functions of Fos phosphorylation in bone homeostasis, cytokine response and tumourigenesis. Oncogene 30, 1506-17
21119595   Curated Info

3

David JP, et al. (2005) Essential role of RSK2 in c-Fos-dependent osteosarcoma development. J Clin Invest 115, 664-72
15719069   Curated Info

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