Tyr605
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Phosphorylation Site Page:
Tyr605 - EphA1 (human)

Site Information
PYVDLQAyEDPAQGA    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: EphA1 (mouse): Y606
Blast this site against: NCBI  SwissProt  PDB 
Available spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
Disease tissue studied: breast cancer (7, 23, 24, 25, 28), breast cancer, triple negative (24, 25), gastric cancer (2, 3, 30), gastric carcinoma (2, 3), liver cancer (5), hepatocellular carcinoma (5), lung cancer (4, 6, 19, 20, 21, 22, 26, 27, 29, 31, 32), non-small cell lung cancer (6, 19, 20, 21, 22, 26, 29, 32), non-small cell lung adenocarcinoma (4)
Relevant cell line - cell type - tissue: AU565 (breast cell) (23), BT-474 (breast cell) (7), Calu-3 (pulmonary) (19, 31), DV-90 (pulmonary) (27), EVSA-T (breast cell) (28), HCC70 (breast cell) (24, 25), HCT116 (intestinal) (1), HepG2 (hepatic) (5), MKN-45 (gastric) (2, 3), NCI-H1437 (pulmonary) (19, 32), NCI-H1781 (pulmonary) (26), NCI-H2342 (pulmonary) (29), NCI-H3255 (pulmonary) (4, 6, 18, 20, 21, 22), SNU-16 (gastric) (30)




References

1

Stokes MP, et al. (2012) PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS. Mol Cell Proteomics 11, 187-201
22322096   Curated Info

2

(2011) CST Curation Set: 12373; Year: 2011; SILAC: N; Biosample/Treatment: MKN-45(cell line)/untreated; Disease: gastric carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

(2011) CST Curation Set: 12374; Year: 2011; SILAC: N; Biosample/Treatment: MKN-45(cell line)/untreated; Disease: gastric carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

4

Moritz A, et al. (2010) Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases. Sci Signal 3, ra64
20736484   Curated Info

5

(2009) CST Curation Set: 7353; Year: 2009; SILAC: N; Biosample/Treatment: HepG2(cell line)/untreated; Disease: hepatocellular carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

6

(2009) CST Curation Set: 7286; Year: 2009; SILAC: N; Biosample/Treatment: NCI-H3255(cell line)/untreated; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

7

(2009) CST Curation Set: 7219; Year: 2009; SILAC: N; Biosample/Treatment: BT-474(cell line)/serum starved; Disease: breast cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

8

(2009) CST Curation Set: 7077; Year: 2009; SILAC: N; Biosample/Treatment: esophagus(tissue)/untreated; Disease: esophageal cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

9

(2009) CST Curation Set: 7011; Year: 2009; SILAC: N; Biosample/Treatment: esophagus(tissue)/untreated; Disease: esophageal cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

10

(2009) CST Curation Set: 7009; Year: 2009; SILAC: N; Biosample/Treatment: esophagus(tissue)/untreated; Disease: esophageal cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

11

(2009) CST Curation Set: 7007; Year: 2009; SILAC: N; Biosample/Treatment: esophagus(tissue)/untreated; Disease: esophageal cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

12

(2009) CST Curation Set: 7008; Year: 2009; SILAC: N; Biosample/Treatment: esophagus(tissue)/untreated; Disease: esophageal cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

13

(2009) CST Curation Set: 7002; Year: 2009; SILAC: N; Biosample/Treatment: esophagus(tissue)/untreated; Disease: esophageal cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

14

(2009) CST Curation Set: 7000; Year: 2009; SILAC: N; Biosample/Treatment: esophagus(tissue)/untreated; Disease: esophageal cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

15

(2009) CST Curation Set: 7001; Year: 2009; SILAC: N; Biosample/Treatment: esophagus(tissue)/untreated; Disease: esophageal cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

16

(2009) CST Curation Set: 6385; Year: 2009; SILAC: N; Biosample/Treatment: SNU-308(cell line)/untreated; Disease: bile-duct cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

17

(2009) CST Curation Set: 6387; Year: 2009; SILAC: N; Biosample/Treatment: SNU-478(cell line)/untreated; Disease: bile-duct cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

18

(2008) CST Curation Set: 5775; Year: 2008; SILAC: N; Biosample/Treatment: NCI-H3255(cell line)/Iressa; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

19

Rikova K, et al. (2007) Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131, 1190-203
18083107   Curated Info

20

(2007) CST Curation Set: 2777; Year: 2007; SILAC: N; Biosample/Treatment: NCI-H3255(cell line)/Iressa; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

21

(2007) CST Curation Set: 2778; Year: 2007; SILAC: N; Biosample/Treatment: NCI-H3255(cell line)/-; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

22

(2007) CST Curation Set: 2488; Year: 2007; SILAC: N; Biosample/Treatment: NCI-H3255(cell line)/untreated; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

23

(2006) CST Curation Set: 1986; Year: 2006; SILAC: N; Biosample/Treatment: AU565(cell line)/serum starved; Disease: breast cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

24

(2006) CST Curation Set: 1992; Year: 2006; SILAC: N; Biosample/Treatment: HCC70(cell line)/serum starved; Disease: breast cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

25

(2006) CST Curation Set: 1993; Year: 2006; SILAC: N; Biosample/Treatment: HCC70(cell line)/serum starved; Disease: breast cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

26

(2006) CST Curation Set: 1921; Year: 2006; SILAC: N; Biosample/Treatment: NCI-H1781(cell line)/serum starved; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

27

(2006) CST Curation Set: 1740; Year: 2006; SILAC: N; Biosample/Treatment: DV-90(cell line)/serum starved; Disease: lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

28

(2006) CST Curation Set: 1701; Year: 2006; SILAC: N; Biosample/Treatment: EVSA-T(cell line)/serum starved; Disease: breast cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

29

(2006) CST Curation Set: 1696; Year: 2006; SILAC: N; Biosample/Treatment: NCI-H2342(cell line)/serum starved; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

30

(2006) CST Curation Set: 1643; Year: 2006; SILAC: N; Biosample/Treatment: SNU-16(cell line)/untreated; Disease: gastric carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

31

(2005) CST Curation Set: 887; Year: 2005; SILAC: N; Biosample/Treatment: Calu-3(cell line)/serum starved; Disease: lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

32

(2005) CST Curation Set: 806; Year: 2005; SILAC: N; Biosample/Treatment: NCI-H1437(cell line)/serum starved; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

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