Ser85

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Phosphorylation Site Page:

Site Information

HRRSRSRsYSRDYRR SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: SFRS10 (human): S85, SFRS10 (rat): S85

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	mass spectrometry (1, 2, 3, 4, 5)
Disease tissue studied:	melanoma skin cancer (5)
Relevant cell line - cell type - tissue:	brain (4), macrophage-bone marrow (3), macrophage-bone marrow [MKP-1 (mouse), homozygous knockout] (3), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (1), skin [mGluR1 (mouse), transgenic, TG mutant mice] (5), spleen (2)

	References

1	Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6 21659605 Curated Info
2	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info
3	Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371 20531401 Curated Info
4	Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9 20415495 Curated Info
5	Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26 19367708 Curated Info

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