Ser1839

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Phosphorylation Site Page:

Ser1839 - AKAP13 (mouse)

Site Information

QPKERPRsAVLLADE SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: AKAP13 (human): S1876, AKAP13 iso2 (human): S1880, AKAP13 iso4 (human): S1858, AKAP13 (rat): S1838

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	mass spectrometry (1, 2, 3, 4, 5, 6, 8, 9, 10, 11)
Disease tissue studied:	anthrax (3), melanoma skin cancer (9)
Relevant cell line - cell type - tissue:	'fat, brown'-'fat, brown' (4), 32Dcl3 (myeloid) (6), 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ~aa 525-695 ETILLNS...IFEYCC)] (6), brain (4), fibroblast-lung (8), heart (4), Hepa 1-6 (epithelial) (10), kidney (4), liver (11), lung (4), macrophage-bone marrow (5), macrophage-bone marrow [MKP-1 (mouse), homozygous knockout] (5), MEF (fibroblast) (2), MEF (fibroblast) [p53 (mouse), homozygous knockout] (1), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (2), skin [mGluR1 (mouse), transgenic, TG mutant mice] (9), spleen (3, 4)

	References

1	Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22 21659604 Curated Info
2	Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6 21659605 Curated Info
3	Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927 21189417 Curated Info
4	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info
5	Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371 20531401 Curated Info
6	Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39 19854140 Curated Info
7	(2009) CST Curation Set: 6842; Year: 2009; Biosample: fibroblast(lung); Disease: -; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-RXX(s/t)(phosphorylation) Antibody Used to Purify Peptides prior to MS2: Phospho-Akt Substrate (RXRXXS/T) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS/T) Immunoaffinity Beads Cat#: 1979 Curated Info
8	(2009) CST Curation Set: 6756; Year: 2009; Biosample: fibroblast(lung); Disease: -; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-RXX(s/t)(phosphorylation) Antibody Used to Purify Peptides prior to MS2: Phospho-Akt Substrate (RXRXXS/T) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS/T) Immunoaffinity Beads Cat#: 1979 Curated Info
9	Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26 19367708 Curated Info
10	Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46 18846507 Curated Info
11	Villén J, Beausoleil SA, Gerber SA, Gygi SP (2007) Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A 104, 1488-93 17242355 Curated Info

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