Ser2716
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Phosphorylation Site Page:
Ser2716 - FAM44A (mouse)

Site Information
RKPDYSSsEEELDDS    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: FAM44A (human): S2780
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 8)
Relevant cell line - cell type - tissue: 32Dcl3 (myeloid) (6), 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ~aa 525-695 ETILLNS...IFEYCC)] (6), brain (5), macrophage-bone marrow (4), macrophage-bone marrow [MKP-1 (mouse), homozygous knockout] (4), MEF (fibroblast) [p53 (mouse), homozygous knockout] (1), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (2), P19 (testicular) (8), testis (3)




References

1

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

2

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

3

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

4

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

5

Wiƛniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

6

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

7

(2009) CST Curation Set: 7382; Year: 2009; SILAC: N; Biosample/Treatment: brain(tissue)/untreated; Disease: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-QX(s/t)(phosphorylation)
Curated Info

8

Smith JC, et al. (2007) A differential phosphoproteomic analysis of retinoic acid-treated P19 cells. J Proteome Res 6, 3174-86
17622165   Curated Info

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