Ser352
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Phosphorylation Site Page:
Ser352 - p90RSK (mouse)

Site Information
TSRTPRDsPGIPPSA    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: p90RSK (rat): S363, p90RSK (chicken): S381, p90RSK (human): S363, p90RSK iso2 (human): S372, p90RSK iso3 (mouse):
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: flow cytometry (6), mass spectrometry (3, 5, 7), phospho-antibody (2, 4, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18), western blotting (2, 4, 6, 8, 9, 10, 12, 14, 16)
Disease tissue studied: breast cancer (10)
Relevant cell line - cell type - tissue: 'brain, cerebral cortex' (13), 'brain, striatum' (17), 'neuron, hippocampal'-brain [neurogranin (mouse)] (16), 32Dcl3 (myeloid) (7), 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ~aa 525-695 ETILLNS...IFEYCC)] (7), 3T3 (fibroblast) (9), brain (3), colon (4), dendritic cell (9), dendritic cell [MAPKAPK2 (mouse), homozygous knockout] (9), dendritic cell [MSK1 (mouse), homozygous knockout] (9), HC11 (epithelial) (8), heart (11), hepatocyte-liver (14), JB (epithelial) (12), kidney (3), lung (3), macrophage-bone marrow (5), macrophage-bone marrow [MKP-1 (mouse), homozygous knockout] (5), MEF (fibroblast) (14, 18), Mel-Ab (melanocyte) (2, 15), NMuMG (epithelial) (8), spleen (3), T lymphocyte-lymph node (6), T47D (breast cell) (10)

Controlled by
Regulatory protein: neurogranin (mouse) (16)
Treatments: anti-CTLA-4 (6), bacterial infection (4), BIRB0796 (9), EGCG (12), EGF (8, 14), forskolin (16), insulin (14), ischemia/reperfusion (11), LPA (15), LPS (5, 9), LY294002 (6), NP68 (6), PD184352 (9, 14), phorbol ester (16), PP2 (6), PRL (8), rapamycin (6, 14), S1P (2), SB203580 (9), TGF-beta (17), Theaflavins (12), TTX (13), U0126 (6), UV (12, 18), visual experience (13)

Downstream Regulation
Effects of modification on p90RSK: enzymatic activity, induced (15)


References

1

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

2

Kim DS, et al. (2011) Sphingosine-1-phosphate decreases melanin synthesis via microphthalmia-associated transcription factor phosphorylation through the S1P3 receptor subtype. J Pharm Pharmacol 63, 409-16
21749389   Curated Info

3

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

4

Chandrakesan P, et al. (2010) Novel changes in NF-{kappa}B activity during progression and regression phases of hyperplasia: role of MEK, ERK, and p38. J Biol Chem 285, 33485-98
20710027   Curated Info

5

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

6

Salmond RJ, Emery J, Okkenhaug K, Zamoyska R (2009) MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells. J Immunol 183, 7388-97
19917692   Curated Info

7

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

8

Haines E, et al. (2009) Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation. Mol Cell Biol 29, 2505-20
19273609   Curated Info

9

Zaru R, et al. (2007) The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nat Immunol 8, 1227-35
17906627   Curated Info

10

Vicent GP, et al. (2006) Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3. Mol Cell 24, 367-81
17081988   Curated Info

11

Maekawa N, et al. (2006) Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury. Circulation 113, 2516-23
16717153   Curated Info

12

Zykova TA, et al. (2005) The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols. Carcinogenesis 26, 331-42
15550455   Curated Info

13

Suzuki S, al-Noori S, Butt SA, Pham TA (2004) Regulation of the CREB signaling cascade in the visual cortex by visual experience and neuronal activity. J Comp Neurol 479, 70-83
15389611   Curated Info

14

Pende M, et al. (2004) S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol Cell Biol 24, 3112-24
15060135   Curated Info

15

Kim DS, et al. (2004) Effects of lysophosphatidic acid on melanogenesis. Chem Phys Lipids 127, 199-206
14726002   Curated Info

16

Wu J, Li J, Huang KP, Huang FL (2002) Attenuation of protein kinase C and cAMP-dependent protein kinase signal transduction in the neurogranin knockout mouse. J Biol Chem 277, 19498-505
11912190   Curated Info

17

Zhu Y, et al. (2002) Transforming growth factor-beta 1 increases bad phosphorylation and protects neurons against damage. J Neurosci 22, 3898-909
12019309   Curated Info

18

Zhang Y, et al. (2001) UVA induces Ser381 phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK pathways. J Biol Chem 276, 14572-80
11278279   Curated Info

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