Ser241

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Phosphorylation Site Page:

Site Information

SSSSLEKsYELPDGQ SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: ACTA1 (human): S241, ACTA1 (rat): S241, ACTA1 (rabbit): S241

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	mass spectrometry (1, 2, 3, 4, 5, 6)
Disease tissue studied:	anthrax (1), melanoma skin cancer (4)
Relevant cell line - cell type - tissue:	brain (2, 3, 6), heart (2), Hepa 1-6 (epithelial) (5), kidney (2), lung (2), skin [mGluR1 (mouse), transgenic, TG mutant mice] (4), spleen (1, 2)

	References

1	Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927 21189417 Curated Info
2	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info
3	Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9 20415495 Curated Info
4	Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26 19367708 Curated Info
5	Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46 18846507 Curated Info
6	Ballif BA, Carey GR, Sunyaev SR, Gygi SP (2008) Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. J Proteome Res 7, 311-8 18034455 Curated Info

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