Thr330
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Phosphorylation Site Page:
Thr330 - JIP4 (human)

Site Information
QETRNVStGSAENEE    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: JIP4 (rat): T316, JIP4 (mouse): T330, JIP4 iso2 (human): T316, JIP4 iso2 (mouse): T316, JIP4 iso3 (mouse): T173
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 3, 4, 5, 6)
Disease tissue studied: lung cancer (3), non-small cell lung adenocarcinoma (3)
Relevant cell line - cell type - tissue: 293E (epithelial) (1), Jurkat (T lymphocyte) (6), NCI-H1703 (squamous) (5), NCI-H3255 (pulmonary) (3, 4)




References

1

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

2

Phanstiel DH, et al. (2011) Proteomic and phosphoproteomic comparison of human ES and iPS cells. Nat Methods 8, 821-7
21983960   Curated Info

3

Moritz A, et al. (2010) Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases. Sci Signal 3, ra64
20736484   Curated Info

4

(2008) CST Curation Set: 5617; Year: 2008; SILAC: N; Biosample/Treatment: NCI-H3255(cell line)/wortmannin; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-RXX(s/t)(phosphorylation) Antibody Used to Purify Peptides prior to MS2: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

5

(2008) CST Curation Set: 4976; Year: 2008; SILAC: N; Biosample/Treatment: NCI-H1703(cell line)/wortmannin; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-RXX(s/t)(phosphorylation) Antibody Used to Purify Peptides prior to MS2: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

6

(2006) CST Curation Set: 2121; Year: 2006; SILAC: N; Biosample/Treatment: Jurkat(cell line)/calyculin & pervanadate; Disease: T cell leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-RXX(s/t)(phosphorylation) Antibody Used to Purify Peptides prior to MS2: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

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