Tyr721

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Phosphorylation Site Page:

Tyr721 - Kit (human)

Site Information

CSDSTNEyMDMKPGV SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: Kit (mouse): Y723

Blast this site against: NCBI SwissProt PDB

Available spectra: 3 CST

In vivo Characterization

Methods used to characterize site in vivo:	mass spectrometry (8, 12, 13, 16, 18, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 54), mass spectrometry (in vitro) (7), mutation of modification site (1, 53, 56), phospho-antibody (6, 17, 35, 55, 56), western blotting (1, 6, 17, 35, 55, 56)
Disease tissue studied:	bone cancer (23), Ewing's sarcoma (23), brain cancer (38), glioblastoma (38), glioma (38), breast cancer (25, 26), colorectal cancer (17, 35), colorectal carcinoma (17, 35), gastric cancer (35, 55), GIST (35, 55), leukemia (6, 29, 32, 33, 34, 36, 37, 43, 44, 46, 47, 50, 51), acute myelogenous leukemia (6, 29, 32, 33, 34, 36, 37, 43, 44, 46, 47, 50, 51), lung cancer (17, 21, 30, 31, 42, 45, 49, 52, 54), non-small cell lung cancer (17, 21, 31, 42, 45, 52), non-small cell squamous cell lung carcinoma (17), small-cell lung cancer (49, 54), lymphoma (48), anaplastic large cell lymphoma (48), neuroblastoma (13, 18), melanoma skin cancer (8, 12, 16), small intestine cancer (55)
Relevant cell line - cell type - tissue:	293 (epithelial) (1), A549 (pulmonary) (17), CHRF (megakaryocyte) (29, 46), COS (fibroblast) (56), DMS153 (pulmonary) (39, 40, 41), DMS79 (pulmonary) (49), DV-90 (pulmonary) (30), EFM-19 (breast cell) (28), GAMG (glial) (38), GI-LI-N (neuron) (27), GIST544 (gastric) (55), GIST882 (gastric) (35, 55), HCC1599 (breast cell) (25, 26), HCT116 (intestinal) (17, 35), HEL (erythroid) (33, 34, 44), IC2 (mast) (53), Jurkat (T lymphocyte) (22), Kasumi-1 (myeloid) (6, 37), LAN-6 (neural crest) (13), lung (21, 31, 42), lymphoid-blood (48), M-07e (myeloid) (50), ME-F2 (myeloid) (36), MKPL-1 (megakaryoblast) (24, 32), NCI-H1299 (pulmonary) (17), NCI-H1650 (pulmonary) (17), NCI-H1693 (pulmonary) (21, 45), NCI-H1703 (squamous) (17, 21, 52), NCI-H23 (pulmonary) (17), NCI-H460 (pulmonary) (17), NCI-H526 (pulmonary) (54), OCI-M1 (myeloid) (43), SK-ES-1 (23), skin (8, 12, 16), SMS-KCN (neural crest) (18), UT-7 (myeloid) (47, 51)

Controlled by

Regulatory protein:	LKB1 (human) (17)
Kinases, in vitro:	Kit (human) (7)
Treatments:	2-deoxyglucose (10), bortezomib (6), DRB (35), flavopiridol (35), imatinib (35, 55), SCF (55, 56), siRNA (17)

Downstream Regulation

Effects of modification on Kit:	activation (1)
Effects of modification on biological processes:	cell adhesion, altered (53)

Disease / Diagnostics Relevance

Relevant diseases:

GIST (55)

	References

1	Phung B, et al. (2011) C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferation. PLoS One 6, e24064 21887372 Curated Info
2	(2010) CST Curation Set: 10551; Year: 2010; Biosample: SK-N-BE(2) TrkA CFP; Disease: neuroblastoma; Treatment: NGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
3	(2010) CST Curation Set: 10549; Year: 2010; Biosample: SK-N-BE(2) TrkA CFP; Disease: neuroblastoma; Treatment: NGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
4	(2010) CST Curation Set: 10550; Year: 2010; Biosample: SK-N-BE(2) TrkA CFP; Disease: neuroblastoma; Treatment: NGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
5	(2010) CST Curation Set: 10548; Year: 2010; Biosample: SK-N-BE(2) TrkA CFP; Disease: neuroblastoma; Treatment: NGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
6	Liu S, et al. (2010) Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia. Cancer Cell 17, 333-47 20385359 Curated Info
7	DiNitto JP, et al. (2010) Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance. J Biochem 147, 601-9 20147452 Curated Info
8	(2009) CST Curation Set: 8384; Year: 2009; Biosample: YA-31; Disease: melanoma skin cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
9	(2009) CST Curation Set: 8060; Year: 2009; Biosample: HY-92T; Disease: gastric cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
10	Zhong D, et al. (2009) The Glycolytic Inhibitor 2-Deoxyglucose Activates Multiple Prosurvival Pathways through IGF1R. J Biol Chem 284, 23225-33 19574224 Curated Info
11	(2009) CST Curation Set: 7526; Year: 2009; Biosample: RJ-z155036T; Disease: liver cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
12	(2009) CST Curation Set: 6397; Year: 2009; Biosample: YA-14; Disease: melanoma skin cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
13	(2009) CST Curation Set: 6125; Year: 2012; Biosample: LAN-6; Disease: neuroblastoma; Treatment: NGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
14	(2008) CST Curation Set: 5604; Year: 2008; Biosample: XY3-246T; Disease: gastric carcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
15	(2008) CST Curation Set: 5513; Year: 2008; Biosample: XY3-198T; Disease: gastric cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
16	(2008) CST Curation Set: 5434; Year: 2008; Biosample: YAC-4; Disease: melanoma skin cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
17	Zhong D, et al. (2008) LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins. Cancer Res 68, 7270-7 18794113 Curated Info
18	(2008) CST Curation Set: 5180; Year: 2012; Biosample: SMS-KCN; Disease: neuroblastoma; Treatment: BDNF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
19	(2008) CST Curation Set: 4091; Year: 2008; Biosample: XY3-130T; Disease: gastric cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
20	(2008) CST Curation Set: 3988; Year: 2008; xenograft; Biosample: XY3-90T; Disease: gastric carcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
21	Rikova K, et al. (2007) Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131, 1190-203 18083107 Curated Info
22	(2007) CST Curation Set: 3410; Year: 2007; Biosample: Jurkat; Disease: T cell leukemia; Treatment: pervanadate; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
23	(2007) CST Curation Set: 3243; Year: 2007; Biosample: SK-ES-1; Disease: Ewing's sarcoma; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
24	Gu TL, et al. (2007) A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia. Blood 110, 323-33 17360941 Curated Info
25	(2006) CST Curation Set: 2107; Year: 2006; Biosample: HCC1599; Disease: breast cancer; Treatment: 0.5% serum; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
26	(2006) CST Curation Set: 2108; Year: 2006; Biosample: HCC1599; Disease: breast cancer; Treatment: 0.5% serum; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
27	(2006) CST Curation Set: 1945; Year: 2006; Biosample: GI-LI-N; Disease: neuroblastoma; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
28	(2006) CST Curation Set: 1813; Year: 2006; Biosample: EFM-19; Disease: breast cancer; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
29	(2006) CST Curation Set: 1791; Year: 2006; Biosample: CHRF; Disease: acute myelogenous leukemia; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
30	(2006) CST Curation Set: 1740; Year: 2006; Biosample: DV-90; Disease: lung cancer; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
31	(2006) CST Curation Set: 1679; Year: 2006; Biosample: lung; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
32	(2006) CST Curation Set: 1557; Year: 2006; Biosample: MKPL-1; Disease: acute myelogenous leukemia; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
33	(2006) CST Curation Set: 1508; Year: 2006; Biosample: HEL; Disease: erythroid leukemia; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
34	(2006) CST Curation Set: 1509; Year: 2006; Biosample: HEL; Disease: erythroid leukemia; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
35	Sambol EB, et al. (2006) Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells. Cancer Res 66, 5858-66 16740725 Curated Info
36	(2006) CST Curation Set: 1399; Year: 2006; Biosample: ME-F2; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
37	(2006) CST Curation Set: 1196; Year: 2006; Biosample: KA-1; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
38	(2006) CST Curation Set: 1146; Year: 2006; Biosample: GAMG; Disease: glioblastoma; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
39	(2006) CST Curation Set: 1078; Year: 2006; Biosample: DMS153; Disease: small-cell lung cancer; Treatment: serum starved & 10% serum; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
40	(2006) CST Curation Set: 1079; Year: 2006; Biosample: DMS153; Disease: small-cell lung cancer; Treatment: serum starved & conditined media; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
41	(2006) CST Curation Set: 1077; Year: 2006; Biosample: DMS153; Disease: small-cell lung cancer; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
42	(2005) CST Curation Set: 952; Year: 2005; Biosample: lung; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
43	(2005) CST Curation Set: 941; Year: 2005; Biosample: OCI-M1; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
44	(2005) CST Curation Set: 943; Year: 2005; Biosample: HEL; Disease: erythroid leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
45	(2005) CST Curation Set: 900; Year: 2005; Biosample: NCI-H1693; Disease: non-small cell lung cancer; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
46	(2005) CST Curation Set: 842; Year: 2005; Biosample: CHRF; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
47	(2005) CST Curation Set: 758; Year: 2005; Biosample: UT-7; Disease: acute myelogenous leukemia; Treatment: elastase; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
48	(2005) CST Curation Set: 742; Year: 2005; Biosample: lymphoid(blood); Disease: lymphoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
49	(2005) CST Curation Set: 734; Year: 2005; Biosample: DMS79; Disease: small-cell lung cancer; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
50	(2005) CST Curation Set: 723; Year: 2005; Biosample: M-07e; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
51	(2005) CST Curation Set: 714; Year: 2005; Biosample: UT-7; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
52	(2005) CST Curation Set: 695; Year: 2005; Biosample: NCI-H1703; Disease: non-small cell lung cancer; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
53	Koma Y, et al. (2005) Distinct role for c-kit receptor tyrosine kinase and SgIGSF adhesion molecule in attachment of mast cells to fibroblasts. Lab Invest 85, 426-35 15654360 Curated Info
54	(2004) CST Curation Set: 447; Year: 2004; Biosample: NCI-H526; Disease: small-cell lung cancer; Treatment: SCF (stem cell factor); Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
55	Duensing A, et al. (2004) Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs). Oncogene 23, 3999-4006 15007386 Curated Info
56	Shivakrupa R, Bernstein A, Watring N, Linnekin D (2003) Phosphatidylinositol 3'-kinase is required for growth of mast cells expressing the kit catalytic domain mutant. Cancer Res 63, 4412-9 12907613 Curated Info
57	Price DJ, et al. (1997) Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. J Biol Chem 272, 5915-20 9038210 Curated Info

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