Ser1217

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Phosphorylation Site Page:

Site Information

DGVFTTSsDMWSFGV SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: InsR (mouse): S1207, InsR (rat): S1218, InsR iso2 (human): S1205

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	[32P] bio-synthetic labeling (1), immunoprecipitation (1), mutation of modification site (1), phospho-antibody (1), western blotting (1)
Relevant cell line - cell type - tissue:	293 (epithelial) (1), 3T3 (fibroblast) [InsR (human)] (1)

Downstream Regulation

Effects of modification on InsR:

enzymatic activity, induced (1)

	References

1	Bossenmaier B, et al. (2000) Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation. Diabetes 49, 889-95 10866039 Curated Info

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