Ser1217
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Phosphorylation Site Page:
Ser1217 - InsR (human)

Site Information
DGVFTTSsDMWSFGV    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: InsR (mouse): S1207, InsR (rat): S1218, InsR iso2 (human): S1205
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: [32P] bio-synthetic labeling (1), immunoprecipitation (1), mutation of modification site (1), phospho-antibody (1), western blotting (1)
Relevant cell line - cell type - tissue: 293 (epithelial) (1), 3T3 (fibroblast) [InsR (human)] (1)


Downstream Regulation
Effects of modification on InsR: enzymatic activity, induced (1)


References

1

Bossenmaier B, et al. (2000) Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation. Diabetes 49, 889-95
10866039   Curated Info

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