Lys15
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Acetylation Site Page:
Lys15 - H3 (rat)

Site Information
ARKSTGGkAPRKQLA    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: H3 (human): K15, H3 (mouse): K15, H3 iso3 (rat): K15, H3 (pig): K15, H3 (chicken): K15, H3 (cow): K15, H3 iso3 (mouse): K15, H3 iso2 (mouse): K15
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458954

In vivo Characterization
Methods used to characterize site in vivo: immunoprecipitation (6), phospho-antibody (6, 7, 9), western blotting (9)
Disease tissue studied: liver cancer (6), hepatocellular carcinoma (6)
Relevant cell line - cell type - tissue: 'brain, hippocampus' (9), HL1C (hepatocyte) (6), RAEC (endothelial) (7)

Controlled by
Treatments: contextual fear conditioning (9), DDTC (9), glucose (6), oxysterol (7), SSZ (9)

Downstream Regulation
Effects of modification on biological processes: chromatin organization, altered (9), transcription, induced (9)


References

1

Lundby A, et al. (2012) Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Rep 2, 419-31
22902405   Curated Info

2

Papadopoulos A, et al. (2011) GABAergic control of novelty stress-responsive epigenetic and gene expression mechanisms in the rat dentate gyrus. Eur Neuropsychopharmacol 21, 316-24
20627472   Curated Info

3

Yakovlev A, et al. (2010) Epigenetic regulation of caspase-3 gene expression in rat brain development. Gene 450, 103-8
19909801   Curated Info

4

Kawakami K, et al. (2009) Age-related difference of site-specific histone modifications in rat liver. Biogerontology 10, 415-21
18814051   Curated Info

5

Tian F, et al. (2009) Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor-mediated activation of Bdnf gene promoter 1. J Neurochem 109, 1375-88
19476549   Curated Info

6

Eckert DT, et al. (2008) Detailed molecular analysis of the induction of the L-PK gene by glucose. Biochem Biophys Res Commun 372, 131-6
18468514   Curated Info

7

Romeo GR, Kazlauskas A (2008) Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. J Biol Chem 283, 9595-605
18230613   Curated Info

8

Ho AK, et al. (2007) Acetylation of histone H3 and adrenergic-regulated gene transcription in rat pinealocytes. Endocrinology 148, 4592-600
17628002   Curated Info

9

Lubin FD, Sweatt JD (2007) The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories. Neuron 55, 942-57
17880897   Curated Info

10

Tang CH, et al. (2007) Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia. J Immunol 179, 1292-302
17617622   Curated Info

11

Sahar S, et al. (2007) Cooperation of SRC-1 and p300 with NF-kappaB and CREB in angiotensin II-induced IL-6 expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 27, 1528-34
17495236   Curated Info

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