Lys401
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Ubiquitination Site Page:
Lys401 - PML (human)

Site Information
KDAAVSKkASPEAAS    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: PML (rat): , PML iso2 (mouse): , PML iso14 (human): K401, PML iso10 (human): K401, PML iso11 (human): K401, PML iso2 (human): K401, PML iso4 (human): K401, PML (mouse): , PML iso3 (human): K401
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 3, 4, 5)
Disease tissue studied: multiple myeloma (4)
Relevant cell line - cell type - tissue: KMS-12-BM (B lymphocyte) (4), U266 (B lymphocyte) (5)




References

1

Kim W, et al. (2011) Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell 44, 325-40
21906983   Curated Info

2

(2010) CST Curation Set: 10366; Year: 2010; Biosample/Treatment: cell line, L363/untreated; Disease: -; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-K-e-GG Antibody Used to Purify Peptides prior to MS2: Ubiquitin (D4A7A10) XP(R) Rabbit mAb Cat#: 3925, PTMScan(R) Ubiquitin Branch Motif (K-e-GG) Immunoaffinity Beads Cat#: 1990
Curated Info

3

(2009) CST Curation Set: 8657; Year: 2009; Biosample/Treatment: cell line, KMS-12-BM/Velcade; Disease: -; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-K-e-GG Antibody Used to Purify Peptides prior to MS2: Ubiquitin (D4A7A10) XP(R) Rabbit mAb Cat#: 3925, PTMScan(R) Ubiquitin Branch Motif (K-e-GG) Immunoaffinity Beads Cat#: 1990
Curated Info

4

(2009) CST Curation Set: 8658; Year: 2009; Biosample/Treatment: cell line, KMS-12-BM/Velcade; Disease: -; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-K-e-GG Antibody Used to Purify Peptides prior to MS2: Ubiquitin (D4A7A10) XP(R) Rabbit mAb Cat#: 3925, PTMScan(R) Ubiquitin Branch Motif (K-e-GG) Immunoaffinity Beads Cat#: 1990
Curated Info

5

(2009) CST Curation Set: 8645; Year: 2009; Biosample/Treatment: cell line, U266/Velcade; Disease: -; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-K-e-GG Antibody Used to Purify Peptides prior to MS2: Ubiquitin (D4A7A10) XP(R) Rabbit mAb Cat#: 3925, PTMScan(R) Ubiquitin Branch Motif (K-e-GG) Immunoaffinity Beads Cat#: 1990
Curated Info

6

Lallemand-Breitenbach V, et al. (2008) Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway. Nat Cell Biol 10, 547-55
18408733   Curated Info

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