Tyr1564
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Phosphorylation Site Page:
Tyr1564 - ITGB4 (human)

Site Information
LQGYSVEyQLLNGGE    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: ITGB4 iso2 (human): Y1494, ITGB4 (rat): Y1548, ITGB4 iso2 (mouse): Y1495, ITGB4 iso3 (human): Y1547, ITGB4 (mouse): Y1560, ITGB4 iso3 (mouse): Y1548
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1), mutation of modification site (2), phospho-antibody (2)
Disease tissue studied: leukemia (1), chronic myelogenous leukemia (1)
Relevant cell line - cell type - tissue: K562 (erythroid) (1), MDA-MB435 (breast cell) (2)

Controlled by
Treatments: vanadate (2)



References

1

(2010) CST Curation Set: 9858; Year: 2010; SILAC: N; Biosample/Treatment: K562(cell line)/normal; Disease: chronic myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

Shaw LM (2001) Identification of insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the alpha6beta4 integrin-dependent activation of phosphoinositide 3-OH kinase and promotion of invasion. Mol Cell Biol 21, 5082-93
11438664   Curated Info

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