Tyr1564

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Phosphorylation Site Page:

Site Information

LQGYSVEyQLLNGGE SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: ITGB4 iso2 (human): Y1494, ITGB4 iso3 (mouse): Y1548, ITGB4 (mouse): Y1560, ITGB4 iso3 (human): Y1547, ITGB4 iso2 (mouse): Y1495, ITGB4 (rat): Y1548

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	mass spectrometry (1), mutation of modification site (2), phospho-antibody (2)
Disease tissue studied:	leukemia (1), chronic myelogenous leukemia (1)
Relevant cell line - cell type - tissue:	K562 (erythroid) (1), MDA-MB435 (breast cell) (2)

Controlled by

Treatments:

vanadate (2)

	References

1	(2010) CST Curation Set: 9858; Year: 2010; Biosample: K562; Disease: chronic myelogenous leukemia; Treatment: normal; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
2	Shaw LM (2001) Identification of insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the alpha6beta4 integrin-dependent activation of phosphoinositide 3-OH kinase and promotion of invasion. Mol Cell Biol 21, 5082-93 11438664 Curated Info

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