Tyr364

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Phosphorylation Site Page:

Site Information

SCFTNQGyFFFHLPD SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: IL2RB (mouse): Y367

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	mutation of modification site (1, 3, 4), phospho-antibody (3, 4)
Relevant cell line - cell type - tissue:	BaF3 ('B lymphocyte, precursor') (3, 4), COS (fibroblast) (4), CTLL (T lymphocyte) (3), HT-2 (T lymphocyte) (1)

Controlled by

Treatments:

IL-2 (3)

Downstream Regulation

Effects of modification on IL2RB:	molecular association, regulation (2, 3, 4)
Effects of modification on biological processes:	transcription, altered (1)
Induce interaction with:	Shc1 (human) (2, 3, 4)

	References

1	Lindemann MJ, et al. (2008) Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway. J Biol Chem 283, 14100-8 18348982 Curated Info
2	Delespine-Carmagnat M, Bouvier G, Bertoglio J (2000) Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain. Eur J Immunol 30, 59-68 10602027 Curated Info
3	Ravichandran KS, et al. (1996) Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling. Proc Natl Acad Sci U S A 93, 5275-80 8643566 Curated Info
4	Evans GA, et al. (1995) Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association. J Biol Chem 270, 28858-63 7499411 Curated Info

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