Tyr738

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Phosphorylation Site Page:

Tyr738 - APP iso8 (human)

Site Information

SKMQQNGyENPTYKF SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: APP iso4 (human): Y682, APP (human): Y757, APP iso2 (mouse): Y682, APP (mouse): Y757, APP iso2 (rat): Y682, APP (rat): Y757

Blast this site against: NCBI SwissProt PDB

Available spectra: 1 CST

In vivo Characterization

Methods used to characterize site in vivo:	mass spectrometry (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16), mutation of modification site (17)
Disease tissue studied:	brain cancer (17), glioblastoma (17), glioma (17), breast cancer (9), colorectal cancer (10, 14), colorectal carcinoma (10, 14), gastric cancer (8), gastric carcinoma (8), lung cancer (8, 15, 16), non-small cell lung cancer (8, 15, 16), non-small cell lung adenocarcinoma (8), pancreatic cancer (12, 13), prostate cancer (11)
Relevant cell line - cell type - tissue:	BxPC-3 (pancreatic) (12, 13), HCC1599 (breast cell) (9), HCC827 (pulmonary) (8), HeLa (cervical) (5), HT-29 (intestinal) (14), MKN-45 (gastric) (3, 4, 8), NCI-H1650 (pulmonary) (8), NCI-H1666 (pulmonary) (8), NCI-H1703 (squamous) (1, 2), NCI-H1734 (pulmonary) (8), NCI-H1975 (pulmonary) (8), NCI-H2228 (pulmonary) (6, 7), NCI-H3255 (pulmonary) (8), NCI-H358 (pulmonary) (8), NCI-H441 (pulmonary) (15, 16), PC3 (prostate cell) (11), SNU-C2B (intestinal) (10), U87MG (glial) (17)

	References

1	(2009) CST Curation Set: 5954; Year: 2009; Biosample: NCI-H1703; Disease: non-small cell lung cancer; Treatment: Gleevec; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
2	(2009) CST Curation Set: 5955; Year: 2009; Biosample: NCI-H1703; Disease: non-small cell lung cancer; Treatment: Gleevec; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
3	(2008) CST Curation Set: 5769; Year: 2008; Biosample: MKN-45; Disease: gastric carcinoma; Treatment: Su11274; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
4	(2008) CST Curation Set: 5771; Year: 2008; Biosample: MKN-45; Disease: gastric carcinoma; Treatment: Su11274; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
5	(2008) CST Curation Set: 5385; Year: 2008; Biosample: HeLa; Disease: cervical adenocarcinoma; Treatment: nocodazole; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
6	(2008) CST Curation Set: 5327; Year: 2008; Biosample: NCI-H2228; Disease: non-small cell lung adenocarcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
7	(2008) CST Curation Set: 5328; Year: 2008; Biosample: NCI-H2228; Disease: non-small cell lung adenocarcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
8	Guo A, et al. (2008) Signaling networks assembled by oncogenic EGFR and c-Met. Proc Natl Acad Sci U S A 105, 692-7 18180459 Curated Info
9	(2006) CST Curation Set: 2108; Year: 2006; Biosample: HCC1599; Disease: breast cancer; Treatment: 0.5% serum; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
10	(2006) CST Curation Set: 1656; Year: 2006; Biosample: SNU-C2B; Disease: colorectal carcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
11	(2004) CST Curation Set: 394; Year: 2004; Biosample: PC3; Disease: prostate cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
12	(2004) CST Curation Set: 378; Year: 2004; SILAC: Y; Biosample1/Treatment/Isotope: BxPC-3/none/L; Biosample2/Treatment/Isotope: BxPC-3/EGF/H; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
13	(2004) CST Curation Set: 379; Year: 2004; SILAC: Y; Biosample1/Treatment/Isotope: BxPC-3/EGF/L; Biosample2/Treatment/Isotope: BxPC-3/EGF/Iressa/H; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
14	(2004) CST Curation Set: 370; Year: 2004; Biosample: HT-29; Disease: colorectal carcinoma; Treatment: Serum starved & IGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
15	(2004) CST Curation Set: 313; Year: 2004; Biosample: NCI-H441; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
16	(2004) CST Curation Set: 315; Year: 2004; Biosample: NCI-H441; Disease: non-small cell lung cancer; Treatment: EGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
17	Jacobsen JS, et al. (1994) The release of Alzheimer's disease beta amyloid peptide is reduced by phorbol treatment. J Biol Chem 269, 8376-82 8132561 Curated Info

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