Tyr132

Javascript is not enabled on this browser. This site will not work properly without Javascript.

Home

Phosphorylation Site Page:

Tyr132 - ZO1 (mouse)

Site Information

SDNEDDSyDEEVHDP SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: ZO1 (rat): Y120, ZO1 (human): Y132, ZO1 iso2 (mouse): Y132, ZO1 iso2 (human): Y132

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	mass spectrometry (1, 2, 3, 4, 5, 6, 8)
Disease tissue studied:	anthrax (3)
Relevant cell line - cell type - tissue:	brain (5), MEF (fibroblast) (1, 2, 8), MEF (fibroblast) [PTP1B (mouse), homozygous knockout] (8), MEF (fibroblast) [raptor (mouse), knockdown] (1), MEF (fibroblast) [rictor (mouse), knockdown] (1), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (2), mpkCCD (renal) (6), spleen (3, 4)

	References

1	Robitaille AM, et al. (2013) Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339, 1320-3 23429704 Curated Info
2	Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6 21659605 Curated Info
3	Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927 21189417 Curated Info
4	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info
5	Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9 20415495 Curated Info
6	Rinschen MM, et al. (2010) Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Proc Natl Acad Sci U S A 107, 3882-7 20139300 Curated Info
7	(2009) CST Curation Set: 7386; Year: 2009; Biosample: heart; Disease: -; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-QX(s/t)(phosphorylation) Curated Info
8	Mertins P, et al. (2008) Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics 7, 1763-77 18515860 Curated Info
9	(2007) CST Curation Set: 2923; Year: 2007; Biosample: heart; Disease: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-(s/t)(D/E)X(D/E)(phosphorylation) Antibody Used to Purify Peptides prior to MS2: Phospho(Ser/Thr) CKII Substrate Antibody (polyAb) Cat#: 5808, PTMScan(R) Phospho-CK Substrate Motif (S/TD/EXD/E) Immunoaffinity Beads Cat#: 1994 Curated Info

Home \| Curator Login	With enhanced literature mining using Linguamatics I2E		Produced by 3rd Millennium \| Design by Digizyme
			©2003-2013 Cell Signaling Technology, Inc.