Tyr732

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Phosphorylation Site Page:

Site Information

DMKPGVSyVVPTKTD SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: Kit (human): Y730

Blast this site against: NCBI SwissProt PDB

Available spectra: 1 CST

In vivo Characterization

Methods used to characterize site in vivo:	flow cytometry (3), immunoprecipitation (3), mass spectrometry (1, 2), mutation of modification site (3), phospho-antibody (3), western blotting (3)
Relevant cell line - cell type - tissue:	32D (myeloid) (3)

Downstream Regulation

Effects of modification on Kit:	activation (3), phosphorylation (3)
Effects of modification on biological processes:	cell cycle regulation (3), cell growth, altered (3)

	References

1	(2006) CST Curation Set: 1516; Year: 2006; Biosample: Thom; Disease: -; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
2	(2006) CST Curation Set: 1517; Year: 2006; Biosample: Thom; Disease: -; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
3	Gommerman JL, et al. (2000) Differential stimulation of c-Kit mutants by membrane-bound and soluble Steel Factor correlates with leukemic potential. Blood 96, 3734-42 11090054 Curated Info

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