Tyr730

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Phosphorylation Site Page:

Tyr730 - Kit (human)

Site Information

DMKPGVSyVVPTKAD SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: Kit (mouse): Y732

Blast this site against: NCBI SwissProt PDB

Available spectra: 2 CST

In vivo Characterization

Methods used to characterize site in vivo:	mass spectrometry (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30), mass spectrometry (in vitro) (4)
Disease tissue studied:	brain cancer (18, 19), glioblastoma (18, 19), glioma (18, 19), breast cancer (9, 10), leukemia (11, 13, 14, 15, 16, 17, 23, 24, 25, 28), acute myelogenous leukemia (11, 13, 14, 15, 16, 17, 23, 24, 25, 28), lung cancer (6, 12, 27, 29, 30), non-small cell lung cancer (6, 12, 29), small-cell lung cancer (27, 30), lymphoma (26), anaplastic large cell lymphoma (26)
Relevant cell line - cell type - tissue:	CHRF (megakaryocyte) (11, 25), DMS153 (pulmonary) (20, 21, 22), DMS79 (pulmonary) (27), GAMG (glial) (18, 19), HCC1599 (breast cell) (9, 10), HEL (erythroid) (14, 15, 24), Jurkat (T lymphocyte) (7), Kasumi-1 (myeloid) (17), lung (6, 12), lymphoid-blood (26), M-07e (myeloid) (28), ME-F2 (myeloid) (16), MKPL-1 (megakaryoblast) (8, 13), NCI-H1703 (squamous) (6, 29), NCI-H526 (pulmonary) (30), OCI-M1 (myeloid) (23)

	References

1	(2010) CST Curation Set: 10551; Year: 2010; Biosample: SK-N-BE(2) TrkA CFP; Disease: neuroblastoma; Treatment: NGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
2	(2010) CST Curation Set: 10549; Year: 2010; Biosample: SK-N-BE(2) TrkA CFP; Disease: neuroblastoma; Treatment: NGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
3	(2010) CST Curation Set: 10550; Year: 2010; Biosample: SK-N-BE(2) TrkA CFP; Disease: neuroblastoma; Treatment: NGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
4	DiNitto JP, et al. (2010) Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance. J Biochem 147, 601-9 20147452 Curated Info
5	(2008) CST Curation Set: 4091; Year: 2008; Biosample: XY3-130T; Disease: gastric cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
6	Rikova K, et al. (2007) Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131, 1190-203 18083107 Curated Info
7	(2007) CST Curation Set: 3410; Year: 2007; Biosample: Jurkat; Disease: T cell leukemia; Treatment: pervanadate; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
8	Gu TL, et al. (2007) A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia. Blood 110, 323-33 17360941 Curated Info
9	(2006) CST Curation Set: 2107; Year: 2006; Biosample: HCC1599; Disease: breast cancer; Treatment: 0.5% serum; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
10	(2006) CST Curation Set: 2108; Year: 2006; Biosample: HCC1599; Disease: breast cancer; Treatment: 0.5% serum; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
11	(2006) CST Curation Set: 1791; Year: 2006; Biosample: CHRF; Disease: acute myelogenous leukemia; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
12	(2006) CST Curation Set: 1679; Year: 2006; Biosample: lung; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
13	(2006) CST Curation Set: 1557; Year: 2006; Biosample: MKPL-1; Disease: acute myelogenous leukemia; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
14	(2006) CST Curation Set: 1508; Year: 2006; Biosample: HEL; Disease: erythroid leukemia; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
15	(2006) CST Curation Set: 1509; Year: 2006; Biosample: HEL; Disease: erythroid leukemia; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
16	(2006) CST Curation Set: 1399; Year: 2006; Biosample: ME-F2; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
17	(2006) CST Curation Set: 1196; Year: 2006; Biosample: KA-1; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
18	(2006) CST Curation Set: 1155; Year: 2006; Biosample: GAMG; Disease: glioblastoma; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
19	(2006) CST Curation Set: 1146; Year: 2006; Biosample: GAMG; Disease: glioblastoma; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
20	(2006) CST Curation Set: 1078; Year: 2006; Biosample: DMS153; Disease: small-cell lung cancer; Treatment: serum starved & 10% serum; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
21	(2006) CST Curation Set: 1079; Year: 2006; Biosample: DMS153; Disease: small-cell lung cancer; Treatment: serum starved & conditined media; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
22	(2006) CST Curation Set: 1077; Year: 2006; Biosample: DMS153; Disease: small-cell lung cancer; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
23	(2005) CST Curation Set: 941; Year: 2005; Biosample: OCI-M1; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
24	(2005) CST Curation Set: 943; Year: 2005; Biosample: HEL; Disease: erythroid leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
25	(2005) CST Curation Set: 842; Year: 2005; Biosample: CHRF; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
26	(2005) CST Curation Set: 742; Year: 2005; Biosample: lymphoid(blood); Disease: lymphoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
27	(2005) CST Curation Set: 734; Year: 2005; Biosample: DMS79; Disease: small-cell lung cancer; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
28	(2005) CST Curation Set: 723; Year: 2005; Biosample: M-07e; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
29	(2005) CST Curation Set: 695; Year: 2005; Biosample: NCI-H1703; Disease: non-small cell lung cancer; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
30	(2004) CST Curation Set: 447; Year: 2004; Biosample: NCI-H526; Disease: small-cell lung cancer; Treatment: SCF (stem cell factor); Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info

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