Tyr730
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Phosphorylation Site Page:
Tyr730 - Kit (human)

Site Information
DMKPGVSyVVPTKAD    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: Kit (mouse): Y732
Blast this site against: NCBI  SwissProt  PDB 
Available spectra:  2 CST

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30), mass spectrometry (in vitro) (4)
Disease tissue studied: brain cancer (18, 19), glioblastoma (18, 19), glioma (18, 19), breast cancer (9, 10), leukemia (11, 13, 14, 15, 16, 17, 23, 24, 25, 28), acute myelogenous leukemia (11, 13, 14, 15, 16, 17, 23, 24, 25, 28), lung cancer (6, 12, 27, 29, 30), non-small cell lung cancer (6, 12, 29), small-cell lung cancer (27, 30), lymphoma (26), anaplastic large cell lymphoma (26)
Relevant cell line - cell type - tissue: CHRF (megakaryocyte) (11, 25), DMS153 (pulmonary) (20, 21, 22), DMS79 (pulmonary) (27), GAMG (glial) (18, 19), HCC1599 (breast cell) (9, 10), HEL (erythroid) (14, 15, 24), Jurkat (T lymphocyte) (7), Kasumi-1 (myeloid) (17), lung (6, 12), lymphoid-blood (26), M-07e (myeloid) (28), ME-F2 (myeloid) (16), MKPL-1 (megakaryoblast) (8, 13), NCI-H1703 (squamous) (6, 29), NCI-H526 (pulmonary) (30), OCI-M1 (myeloid) (23)




References

1

(2010) CST Curation Set: 10551; Year: 2010; SILAC: N; Biosample/Treatment: SKNBE(2)(cell line)/NGF; Disease: neuroblastoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

(2010) CST Curation Set: 10549; Year: 2010; SILAC: N; Biosample/Treatment: SKNBE(2)(cell line)/NGF; Disease: neuroblastoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

(2010) CST Curation Set: 10550; Year: 2010; SILAC: N; Biosample/Treatment: SKNBE(2)(cell line)/NGF; Disease: neuroblastoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

4

DiNitto JP, et al. (2010) Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance. J Biochem 147, 601-9
20147452   Curated Info

5

(2008) CST Curation Set: 4091; Year: 2008; SILAC: N; Biosample/Treatment: gastrointestinal tract(tissue)/untreated; Disease: gastric cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

6

Rikova K, et al. (2007) Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131, 1190-203
18083107   Curated Info

7

(2007) CST Curation Set: 3410; Year: 2007; SILAC: N; Biosample/Treatment: Jurkat(cell line)/pervanadate; Disease: T cell leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

8

Gu TL, et al. (2007) A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia. Blood 110, 323-33
17360941   Curated Info

9

(2006) CST Curation Set: 2107; Year: 2006; SILAC: N; Biosample/Treatment: HCC1599(cell line)/0.5% serum; Disease: breast cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

10

(2006) CST Curation Set: 2108; Year: 2006; SILAC: N; Biosample/Treatment: HCC1599(cell line)/0.5% serum; Disease: breast cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

11

(2006) CST Curation Set: 1791; Year: 2006; SILAC: N; Biosample/Treatment: CHRF(cell line)/untreated; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

12

(2006) CST Curation Set: 1679; Year: 2006; SILAC: N; Biosample/Treatment: lung(tissue)/-; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

13

(2006) CST Curation Set: 1557; Year: 2006; SILAC: N; Biosample/Treatment: MKPL-1(cell line)/untreated; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

14

(2006) CST Curation Set: 1508; Year: 2006; SILAC: N; Biosample/Treatment: HEL(cell line)/untreated; Disease: erythroid leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

15

(2006) CST Curation Set: 1509; Year: 2006; SILAC: N; Biosample/Treatment: HEL(cell line)/untreated; Disease: erythroid leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

16

(2006) CST Curation Set: 1399; Year: 2006; SILAC: N; Biosample/Treatment: ME-F2(cell line)/-; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

17

(2006) CST Curation Set: 1196; Year: 2006; SILAC: N; Biosample/Treatment: Kasumi-1(cell line)/-; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

18

(2006) CST Curation Set: 1155; Year: 2006; SILAC: N; Biosample/Treatment: GAMG(cell line)/serum starved; Disease: glioblastoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

19

(2006) CST Curation Set: 1146; Year: 2006; SILAC: N; Biosample/Treatment: GAMG(cell line)/serum starved; Disease: glioblastoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

20

(2006) CST Curation Set: 1078; Year: 2006; SILAC: N; Biosample/Treatment: DMS153(cell line)/serum starved & 10% serum; Disease: small-cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

21

(2006) CST Curation Set: 1079; Year: 2006; SILAC: N; Biosample/Treatment: DMS153(cell line)/serum starved & conditined media; Disease: small-cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

22

(2006) CST Curation Set: 1077; Year: 2006; SILAC: N; Biosample/Treatment: DMS153(cell line)/serum starved; Disease: small-cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

23

(2005) CST Curation Set: 941; Year: 2005; SILAC: N; Biosample/Treatment: OCI-M1(cell line)/-; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

24

(2005) CST Curation Set: 943; Year: 2005; SILAC: N; Biosample/Treatment: HEL(cell line)/-; Disease: erythroid leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

25

(2005) CST Curation Set: 842; Year: 2005; SILAC: N; Biosample/Treatment: CHRF(cell line)/-; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

26

(2005) CST Curation Set: 742; Year: 2005; SILAC: N; Biosample/Treatment: lymphoid(blood)/-; Disease: lymphoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

27

(2005) CST Curation Set: 734; Year: 2005; SILAC: N; Biosample/Treatment: DMS79(cell line)/serum starved; Disease: small-cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

28

(2005) CST Curation Set: 723; Year: 2005; SILAC: N; Biosample/Treatment: M-07e(cell line)/-; Disease: acute myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

29

(2005) CST Curation Set: 695; Year: 2005; SILAC: N; Biosample/Treatment: NCI-H1703(cell line)/serum starved; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

30

(2004) CST Curation Set: 447; Year: 2004; SILAC: N; Biosample/Treatment: NCI-H526(cell line)/SCF (stem cell factor); Disease: small-cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

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