Ser57
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Phosphorylation Site Page:
Ser57 - PWP1 (human)

Site Information
SDEEETGsPSEDGMQ    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: PWP1 (rat): S56, PWP1 (mouse): N56
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 452815

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 3, 4, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
Disease tissue studied: breast cancer (1), cervical cancer (8), cervical adenocarcinoma (8), leukemia (14), chronic myelogenous leukemia (14)
Relevant cell line - cell type - tissue: 293 (epithelial) (10), 293 (epithelial) [AT1 (human), transfection, AT1R stable transfected HEK293] (7), 293 (epithelial) [AT1 (human), transfection] (6), Flp-In T-Rex-293 (epithelial) (4), Flp-In T-Rex-293 (epithelial) [PRKD1 (human), genetic knockin] (4), HeLa (cervical) (3, 12, 15), HeLa S3 (cervical) (8, 9), Jurkat (T lymphocyte) (11), K562 (erythroid) (3, 13, 14), stem (1), stem [CXCR4 (human), knockdown] (1)

Controlled by
Treatments: nocodazole (8)



References

1

Yi T, et al. (2014) Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A 111, E2182-90
24782546   Curated Info

2

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

3

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

4

Franz-Wachtel M, et al. (2012) Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics 11, 160-70
22496350   Curated Info

5

Phanstiel DH, et al. (2011) Proteomic and phosphoproteomic comparison of human ES and iPS cells. Nat Methods 8, 821-7
21983960   Curated Info

6

Xiao K, et al. (2010) Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci U S A 107, 15299-304
20686112   Curated Info

7

Christensen GL, et al. (2010) Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists. Mol Cell Proteomics 9, 1540-53
20363803   Curated Info

8

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

9

Malik R, et al. (2009) Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages. J Proteome Res 8, 4553-63
19691289   Curated Info

10

Gauci S, et al. (2009) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem 81, 4493-501
19413330   Curated Info

11

Mayya V, et al. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal 2, ra46
19690332   Curated Info

12

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

13

(2008) CST Curation Set: 4609; Year: 2008; Biosample/Treatment: cell line, K562/untreated; Disease: chronic myelogenous leukemia; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-[sty](phosphorylation)
Curated Info

14

(2008) CST Curation Set: 4393; Year: 2008; Biosample/Treatment: cell line, K562/untreated; Disease: chronic myelogenous leukemia; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-[sty](phosphorylation)
Curated Info

15

Beausoleil SA, et al. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A 101, 12130-5
15302935   Curated Info

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