Thr1187

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Phosphorylation Site Page:

Thr1187 - InsR (human)

Site Information

MTRDIYEtDYYRKGG SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: InsR (rat): T1188, InsR iso2 (human): T1175, InsR (mouse): T1177

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	mass spectrometry (1, 2, 3, 6, 7, 16, 17, 18, 19, 21, 22, 23, 25, 27, 28, 31, 32, 33, 34)
Disease tissue studied:	breast cancer (23), gastric cancer (1, 3, 18, 19, 31, 32, 33, 34), gastric carcinoma (1, 3, 18, 19), leukemia (16, 17), chronic myelogenous leukemia (16, 17), liver cancer (28), hepatocellular carcinoma, surrounding tissue (22), lung cancer (2), non-small cell lung cancer (2), non-small cell lung adenocarcinoma (2), neuroblastoma (7), melanoma skin cancer (25, 27)
Relevant cell line - cell type - tissue:	'liver, para-cholangiocellular carcinoma tissue' (6), hepatic-'liver, para-hepatocellular carcinoma tissue' (22), IM95 (gastric) (33), JHH-7 (hepatic) (28), Jurkat (T lymphocyte) (21), K562 (erythroid) (16, 17), LAN-6 (neural crest) (7), MDA-MB361 (breast cell) (23), MKN-45 (gastric) (1, 3, 18, 19), NCI-H3122 (pulmonary) (2), OCUM-1 (gastric) (31), RERF-GC-1B (gastric) (32), SCH (gastric) (34), skin (25, 27)

	References

1	(2011) CST Curation Set: 12373; Year: 2011; Biosample: MKN-45; Disease: gastric carcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
2	(2011) CST Curation Set: 11919; Year: 2011; Biosample: NCI-H3122; Disease: non-small cell lung cancer; Treatment: normal; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
3	(2011) CST Curation Set: 11925; Year: 2011; Biosample: MKN-45; Disease: gastric carcinoma; Treatment: normal; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
4	(2011) CST Curation Set: 11781; Year: 2011; Biosample: RP98; Disease: non-small cell lung adenocarcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
5	(2011) CST Curation Set: 11791; Year: 2011; Biosample: FAC 13T; Disease: non-small cell lung adenocarcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
6	Gu TL, et al. (2011) Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS One 6, e15640 21253578 Curated Info
7	(2010) CST Curation Set: 10554; Year: 2010; Biosample: LAN-6; Disease: neuroblastoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
8	(2010) CST Curation Set: 10552; Year: 2010; Biosample: SK-N-BE(2) TrkA CFP; Disease: neuroblastoma; Treatment: NGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
9	(2010) CST Curation Set: 10551; Year: 2010; Biosample: SK-N-BE(2) TrkA CFP; Disease: neuroblastoma; Treatment: NGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
10	(2010) CST Curation Set: 10549; Year: 2010; Biosample: SK-N-BE(2) TrkA CFP; Disease: neuroblastoma; Treatment: NGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
11	(2010) CST Curation Set: 10205; Year: 2010; Biosample: XY1-OC30; Disease: ovarian cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411 Curated Info
12	(2010) CST Curation Set: 10132; Year: 2010; Biosample: XY1-B20; Disease: ovarian epithelial carcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411 Curated Info
13	(2010) CST Curation Set: 10078; Year: 2010; Biosample: SH-SY5Y; Disease: neuroblastoma; Treatment: inhibitor; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
14	(2010) CST Curation Set: 10040; Year: 2010; Biosample: DFCI ERC17; Disease: -; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
15	(2010) CST Curation Set: 9979; Year: 2010; Biosample: MKN-45; Disease: gastric carcinoma; Treatment: DMSO; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-[sty](phosphorylation) Curated Info
16	(2010) CST Curation Set: 9858; Year: 2010; Biosample: K562; Disease: chronic myelogenous leukemia; Treatment: normal; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
17	(2010) CST Curation Set: 9856; Year: 2010; Biosample: K562; Disease: chronic myelogenous leukemia; Treatment: normal; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
18	(2010) CST Curation Set: 9790; Year: 2010; Biosample: MKN-45; Disease: gastric carcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
19	(2010) CST Curation Set: 9236; Year: 2010; Biosample: MKN-45; Disease: gastric carcinoma; Treatment: pervanadate & calyculin; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-[sty](phosphorylation) Curated Info
20	(2010) CST Curation Set: 8711; Year: 2010; Biosample: HR131N; Disease: lung cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
21	(2009) CST Curation Set: 8804; Year: 2009; Biosample: Jurkat; Disease: T cell leukemia; Treatment: pervanadate & calyculin; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
22	(2009) CST Curation Set: 7537; Year: 2009; Biosample: hepatic(liver, para-hepatocellular carcinoma tissue); Disease: liver cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
23	(2009) CST Curation Set: 7220; Year: 2009; Biosample: MDA-MB361; Disease: breast cancer; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
24	(2009) CST Curation Set: 6680; Year: 2009; Biosample: Dana Farber BEAS; Disease: -; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
25	(2009) CST Curation Set: 6425; Year: 2009; Biosample: YAC-16; Disease: melanoma skin cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
26	(2009) CST Curation Set: 6483; Year: 2009; Biosample: RP-25; Disease: non-small cell lung adenocarcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
27	(2009) CST Curation Set: 6396; Year: 2009; Biosample: YAC-18; Disease: melanoma skin cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
28	(2009) CST Curation Set: 5976; Year: 2009; Biosample: JHH-7; Disease: liver cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
29	(2008) CST Curation Set: 4794; Year: 2008; Biosample: SloanK ERMS 7335; Disease: -; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
30	(2008) CST Curation Set: 4215; Year: 2008; Biosample: XY2-WYN5; Disease: -; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
31	(2008) CST Curation Set: 3920; Year: 2008; Biosample: OCUM-1; Disease: gastric cancer; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
32	(2008) CST Curation Set: 3921; Year: 2008; Biosample: RERF-GC-1B; Disease: gastric cancer; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
33	(2008) CST Curation Set: 3917; Year: 2008; Biosample: IM95; Disease: gastric cancer; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
34	(2008) CST Curation Set: 3794; Year: 2008; Biosample: SCH; Disease: gastric cancer; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
35	(2007) CST Curation Set: 3472; Year: 2007; Biosample: MGH-R; Disease: ovarian cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
36	(2007) CST Curation Set: 3442; Year: 2007; Biosample: MGH-K; Disease: ovarian cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info

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