Thr1187
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Phosphorylation Site Page:
Thr1187 - InsR (human)

Site Information
MTRDIYEtDYYRKGG    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: InsR (rat): T1188, InsR iso2 (human): T1175, InsR (mouse): T1177
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 6, 7, 8, 9, 10, 18, 19, 20, 21, 23, 24, 25, 27, 29, 30, 33, 34, 35, 36, 39)
Disease tissue studied: brain cancer (39), glioblastoma (39), glioma (39), breast cancer (25), gastric cancer (1, 3, 20, 21, 33, 34, 35, 36), gastric carcinoma (1, 3, 20, 21), leukemia (18, 19), chronic myelogenous leukemia (18, 19), liver cancer (30), hepatocellular carcinoma, surrounding tissue (24), lung cancer (2), non-small cell lung cancer (2), non-small cell lung adenocarcinoma (2), neuroblastoma (10), melanoma skin cancer (27, 29), ventricular tachycardia (6, 7)
Relevant cell line - cell type - tissue: 'liver, para-cholangiocellular carcinoma tissue' (8), cardiac-heart (6, 7), hepatic-'liver, para-hepatocellular carcinoma tissue' (24), HES-3 ('stem, embryonic') (9), IM95 (gastric) (35), JHH-7 (hepatic) (30), Jurkat (T lymphocyte) (23), K562 (erythroid) (18, 19), LAN-6 (neural crest) (10), M059K (glial) (39), MDA-MB361 (breast cell) (25), MKN-45 (gastric) (1, 3, 20, 21), NCI-H3122 (pulmonary) (2), OCUM-1 (gastric) (33), RERF-GC-1B (gastric) (34), SCH (gastric) (36), skin (27, 29)




References

1

(2011) CST Curation Set: 12373; Year: 2011; SILAC: N; Biosample/Treatment: MKN-45(cell line)/untreated; Disease: gastric carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

(2011) CST Curation Set: 11919; Year: 2011; SILAC: N; Biosample/Treatment: NCI-H3122(cell line)/normal; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

(2011) CST Curation Set: 11925; Year: 2011; SILAC: N; Biosample/Treatment: MKN-45(cell line)/normal; Disease: gastric carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

4

(2011) CST Curation Set: 11781; Year: 2011; SILAC: N; Biosample/Treatment: RP98(tissue)/untreated; Disease: non-small cell lung adenocarcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

5

(2011) CST Curation Set: 11791; Year: 2011; SILAC: N; Biosample/Treatment: FAC 13T(tissue)/untreated; Disease: non-small cell lung adenocarcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

6

(2011) CST Curation Set: 10448; Year: 2011; SILAC: N; Biosample/Treatment: heart(tissue)/untreated; Disease: ventricular tachycardia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

7

(2011) CST Curation Set: 10454; Year: 2011; SILAC: N; Biosample/Treatment: heart(tissue)/untreated; Disease: ventricular tachycardia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

8

Gu TL, et al. (2011) Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS One 6, e15640
21253578   Curated Info

9

Ding VM, et al. (2011) Tyrosine phosphorylation profiling in fgf-2 stimulated human embryonic stem cells. PLoS One 6, e17538
21437283   Curated Info

10

(2010) CST Curation Set: 10554; Year: 2010; SILAC: N; Biosample/Treatment: LAN-6(cell line)/untreated; Disease: neuroblastoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

11

(2010) CST Curation Set: 10552; Year: 2010; SILAC: N; Biosample/Treatment: SKNBE(2)(cell line)/NGF; Disease: neuroblastoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

12

(2010) CST Curation Set: 10551; Year: 2010; SILAC: N; Biosample/Treatment: SKNBE(2)(cell line)/NGF; Disease: neuroblastoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

13

(2010) CST Curation Set: 10549; Year: 2010; SILAC: N; Biosample/Treatment: SKNBE(2)(cell line)/NGF; Disease: neuroblastoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

14

(2010) CST Curation Set: 10132; Year: 2010; SILAC: N; Biosample/Treatment: ovary(tissue)/untreated; Disease: ovarian epithelial carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411
Curated Info

15

(2010) CST Curation Set: 10078; Year: 2010; SILAC: N; Biosample/Treatment: SH-SY5Y(cell line)/inhibitor; Disease: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

16

(2010) CST Curation Set: 10040; Year: 2010; SILAC: N; Biosample/Treatment: DFCI ERC17(cell line)/untreated; Disease: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

17

(2010) CST Curation Set: 9979; Year: 2010; SILAC: N; Biosample/Treatment: MKN-45(cell line)/DMSO; Disease: gastric carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-[sty](phosphorylation)
Curated Info

18

(2010) CST Curation Set: 9858; Year: 2010; SILAC: N; Biosample/Treatment: K562(cell line)/normal; Disease: chronic myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

19

(2010) CST Curation Set: 9856; Year: 2010; SILAC: N; Biosample/Treatment: K562(cell line)/normal; Disease: chronic myelogenous leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

20

(2010) CST Curation Set: 9790; Year: 2010; SILAC: N; Biosample/Treatment: MKN-45(cell line)/untreated; Disease: gastric carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

21

(2010) CST Curation Set: 9236; Year: 2010; SILAC: N; Biosample/Treatment: MKN-45(cell line)/pervanadate & calyculin; Disease: gastric carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-[sty](phosphorylation)
Curated Info

22

(2010) CST Curation Set: 8711; Year: 2010; SILAC: N; Biosample/Treatment: lung(tissue)/untreated; Disease: lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

23

(2009) CST Curation Set: 8804; Year: 2009; SILAC: N; Biosample/Treatment: Jurkat(cell line)/pervanadate & calyculin; Disease: T cell leukemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

24

(2009) CST Curation Set: 7537; Year: 2009; SILAC: N; Biosample/Treatment: hepatic(liver, para-hepatocellular carcinoma tissue)/untreated; Disease: liver cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

25

(2009) CST Curation Set: 7220; Year: 2009; SILAC: N; Biosample/Treatment: MDA-MB361(cell line)/serum starved; Disease: breast cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

26

(2009) CST Curation Set: 6680; Year: 2009; SILAC: N; Biosample/Treatment: Dana Farber BEAS(cell line)/untreated; Disease: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

27

(2009) CST Curation Set: 6425; Year: 2009; SILAC: N; Biosample/Treatment: skin(tissue)/untreated; Disease: melanoma skin cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

28

(2009) CST Curation Set: 6483; Year: 2009; SILAC: N; Biosample/Treatment: lung(tissue)/untreated; Disease: non-small cell lung adenocarcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

29

(2009) CST Curation Set: 6396; Year: 2009; SILAC: N; Biosample/Treatment: skin(tissue)/untreated; Disease: melanoma skin cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

30

(2009) CST Curation Set: 5976; Year: 2009; SILAC: N; Biosample/Treatment: JHH-7(cell line)/untreated; Disease: liver cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

31

(2008) CST Curation Set: 4794; Year: 2008; SILAC: N; Biosample/Treatment: SloanK ERMS 7335(tissue)/untreated; Disease: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

32

(2008) CST Curation Set: 4215; Year: 2008; SILAC: N; Biosample/Treatment: heart(tissue)/untreated; Disease: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

33

(2008) CST Curation Set: 3920; Year: 2008; SILAC: N; Biosample/Treatment: OCUM-1(cell line)/serum starved; Disease: gastric cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

34

(2008) CST Curation Set: 3921; Year: 2008; SILAC: N; Biosample/Treatment: RERF-GC-1B(cell line)/serum starved; Disease: gastric cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

35

(2008) CST Curation Set: 3917; Year: 2008; SILAC: N; Biosample/Treatment: IM95(cell line)/serum starved; Disease: gastric cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

36

(2008) CST Curation Set: 3794; Year: 2008; SILAC: N; Biosample/Treatment: SCH(cell line)/serum starved; Disease: gastric cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

37

(2007) CST Curation Set: 3472; Year: 2007; SILAC: N; Biosample/Treatment: ovary(tissue)/untreated; Disease: ovarian cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

38

(2007) CST Curation Set: 3442; Year: 2007; SILAC: N; Biosample/Treatment: ovary(tissue)/untreated; Disease: ovarian cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

39

(2007) CST Curation Set: 2265; Year: 2007; SILAC: N; Biosample/Treatment: M059K(cell line)/UV; Disease: glioblastoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-(s/t)Q(phosphorylation) Antibody Used to Purify Peptides prior to MS2: Phospho-(Ser/Thr) ATM/ATR Substrate Antibody Cat#: 2851
Curated Info

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