Tyr1207
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Phosphorylation Site Page:
Tyr1207 - ITGB4 iso2 (human)

Site Information
GAQGEGPySSLVSCR    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: ITGB4 (human): Y1207, ITGB4 (rat): Y1209, ITGB4 iso2 (mouse): Y1209, ITGB4 iso3 (human): Y1207, ITGB4 (mouse): Y1209, ITGB4 iso3 (mouse): Y1209
Blast this site against: NCBI  SwissProt  PDB 
Available spectra:  2 CST

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
Disease tissue studied: colorectal cancer (13, 14, 15, 16, 17), colorectal carcinoma (13, 14, 15, 16, 17), lung cancer (21), non-small cell lung cancer (21), pancreatic cancer (5, 6, 7, 9, 10, 22, 23, 24, 25, 26), pancreatic carcinoma (6, 7, 22, 25, 26), prostate cancer (8), non-melanoma skin cancer (11, 12, 18, 19, 20)
Relevant cell line - cell type - tissue: A431 (epithelial) (11, 12, 18, 19, 20), BxPC-3 (pancreatic) (5, 9, 10, 23, 24), HPAC (pancreatic) (25, 26), Hs766T (pancreatic) (7, 22), HT-29 (intestinal) (13, 14, 15), MKN-45 (gastric) (1, 2), NCI-H1373 (pulmonary) (21), NCI-H2228 (pulmonary) (3, 4), PC3 (prostate cell) (8), Su.86.86 (pancreatic) (6), SW620 (intestinal) (16, 17)




References

1

(2008) CST Curation Set: 5770; Year: 2008; SILAC: N; Biosample/Treatment: MKN-45(cell line)/Su11274; Disease: gastric carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

(2008) CST Curation Set: 5771; Year: 2008; SILAC: N; Biosample/Treatment: MKN-45(cell line)/Su11274; Disease: gastric carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

(2008) CST Curation Set: 5327; Year: 2008; SILAC: N; Biosample/Treatment: NCI-H2228(cell line)/untreated; Disease: non-small cell lung adenocarcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

4

(2008) CST Curation Set: 5328; Year: 2008; SILAC: N; Biosample/Treatment: NCI-H2228(cell line)/untreated; Disease: non-small cell lung adenocarcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

5

(2004) CST Curation Set: 411; Year: 2004; SILAC: Y; Biosample1/Treatment/Isotope: BxPC-3(cell line)/EGF & Iressa/L, Biosample2/Treatment/Isotope: BxPC-3(cell line)/EGF/H; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

6

(2004) CST Curation Set: 413; Year: 2004; SILAC: N; Biosample/Treatment: Su.86.86(cell line)/Serum starved; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

7

(2004) CST Curation Set: 414; Year: 2004; SILAC: N; Biosample/Treatment: Hs766T(cell line)/Serum starved; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

8

(2004) CST Curation Set: 394; Year: 2004; SILAC: N; Biosample/Treatment: PC3(cell line)/-; Disease: prostate cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

9

(2004) CST Curation Set: 378; Year: 2004; SILAC: Y; Biosample1/Treatment/Isotope: BxPC-3(cell line)/none/L, Biosample2/Treatment/Isotope: BxPC-3(cell line)/EGF/H; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

10

(2004) CST Curation Set: 379; Year: 2004; SILAC: Y; Biosample1/Treatment/Isotope: BxPC-3(cell line)/EGF/L, Biosample2/Treatment/Isotope: BxPC-3(cell line)/EGF/Iressa/H; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

11

(2004) CST Curation Set: 371; Year: 2004; SILAC: Y; Biosample1/Treatment/Isotope: A431(cell line)/none/L, Biosample2/Treatment/Isotope: A431(cell line)/EGF/H; Disease: non-melanoma skin cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

12

(2004) CST Curation Set: 372; Year: 2004; SILAC: Y; Biosample1/Treatment/Isotope: A431(cell line)/none/L, Biosample2/Treatment/Isotope: A431(cell line)/EGF/H; Disease: non-melanoma skin cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

13

(2004) CST Curation Set: 368; Year: 2004; SILAC: N; Biosample/Treatment: HT-29(cell line)/Serum starved; Disease: colorectal carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

14

(2004) CST Curation Set: 369; Year: 2004; SILAC: N; Biosample/Treatment: HT-29(cell line)/Serum starved & EGF; Disease: colorectal carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

15

(2004) CST Curation Set: 370; Year: 2004; SILAC: N; Biosample/Treatment: HT-29(cell line)/Serum starved & IGF; Disease: colorectal carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

16

(2004) CST Curation Set: 360; Year: 2004; SILAC: N; Biosample/Treatment: SW620(cell line)/Serum starved; Disease: colorectal carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

17

(2004) CST Curation Set: 361; Year: 2004; SILAC: N; Biosample/Treatment: SW620(cell line)/Serum starved & IGF; Disease: colorectal carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

18

(2004) CST Curation Set: 357; Year: 2004; SILAC: N; Biosample/Treatment: A431(cell line)/-; Disease: non-melanoma skin cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

19

(2004) CST Curation Set: 358; Year: 2004; SILAC: N; Biosample/Treatment: A431(cell line)/EGF; Disease: non-melanoma skin cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

20

(2004) CST Curation Set: 359; Year: 2004; SILAC: N; Biosample/Treatment: A431(cell line)/EGF & Iressa; Disease: non-melanoma skin cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

21

(2004) CST Curation Set: 354; Year: 2004; SILAC: N; Biosample/Treatment: NCI-H1373(cell line)/-; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

22

(2004) CST Curation Set: 400; Year: 2004; SILAC: N; Biosample/Treatment: Hs766T(cell line)/Serum starved; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

23

(2004) CST Curation Set: 249; Year: 2004; SILAC: N; Biosample/Treatment: BxPC-3(cell line)/-; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

24

(2004) CST Curation Set: 252; Year: 2004; SILAC: N; Biosample/Treatment: BxPC-3(cell line)/EGF; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

25

(2004) CST Curation Set: 243; Year: 2004; SILAC: N; Biosample/Treatment: HPAC(cell line)/-; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

26

(2004) CST Curation Set: 246; Year: 2004; SILAC: N; Biosample/Treatment: HPAC(cell line)/-; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

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