Tyr1207
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Phosphorylation Site Page:
Tyr1207 - ITGB4 iso2 (human)

Site Information
GAQGEGPySSLVSCR    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: ITGB4 (human): Y1207, ITGB4 (rat): Y1209, ITGB4 iso2 (mouse): Y1209, ITGB4 iso3 (human): Y1207, ITGB4 (mouse): Y1209, ITGB4 iso3 (mouse): Y1209
Blast this site against: NCBI  SwissProt  PDB 
Available spectra:  2 CST

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
Disease tissue studied: colorectal cancer (15, 16, 17, 18, 19), colorectal carcinoma (15, 16, 17, 18, 19), gastric cancer (5), gastric carcinoma (5), lung cancer (5, 6, 23), non-small cell lung cancer (5, 6, 23), non-small cell lung adenocarcinoma (5, 6), pancreatic cancer (7, 8, 9, 11, 12, 24, 25, 26, 27, 28), pancreatic carcinoma (8, 9, 24, 27, 28), prostate cancer (10), non-melanoma skin cancer (13, 14, 20, 21, 22)
Relevant cell line - cell type - tissue: A431 (epithelial) (13, 14, 20, 21, 22), BxPC-3 (pancreatic) (7, 11, 12, 25, 26), Calu-3 (pulmonary) (6), HCC827 (pulmonary) (5, 6), HPAC (pancreatic) (27, 28), Hs766T (pancreatic) (9, 24), HT-29 (intestinal) (15, 16, 17), lung (6), MKN-45 (gastric) (1, 2, 5), NCI-H1373 (pulmonary) (6, 23), NCI-H1568 (pulmonary) (6), NCI-H1650 (pulmonary) (5, 6), NCI-H1666 (pulmonary) (5, 6), NCI-H1993 (pulmonary) (6), NCI-H2228 (pulmonary) (3, 4), NCI-H2347 (pulmonary) (6), NCI-H3255 (pulmonary) (5, 6), PC3 (prostate cell) (10), Su.86.86 (pancreatic) (8), SW620 (intestinal) (18, 19)




References

1

(2008) CST Curation Set: 5770; Year: 2008; Biosample: MKN-45; Disease: gastric carcinoma; Treatment: Su11274; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

(2008) CST Curation Set: 5771; Year: 2008; Biosample: MKN-45; Disease: gastric carcinoma; Treatment: Su11274; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

(2008) CST Curation Set: 5327; Year: 2008; Biosample: NCI-H2228; Disease: non-small cell lung adenocarcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

4

(2008) CST Curation Set: 5328; Year: 2008; Biosample: NCI-H2228; Disease: non-small cell lung adenocarcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

5

Guo A, et al. (2008) Signaling networks assembled by oncogenic EGFR and c-Met. Proc Natl Acad Sci U S A 105, 692-7
18180459   Curated Info

6

Rikova K, et al. (2007) Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131, 1190-203
18083107   Curated Info

7

(2004) CST Curation Set: 411; Year: 2004; SILAC: Y; Biosample1/Treatment/Isotope: BxPC-3/EGF & Iressa/L; Biosample2/Treatment/Isotope: BxPC-3/EGF/H; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

8

(2004) CST Curation Set: 413; Year: 2004; Biosample: Su.86.86; Disease: pancreatic carcinoma; Treatment: Serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

9

(2004) CST Curation Set: 414; Year: 2004; Biosample: Hs766T; Disease: pancreatic carcinoma; Treatment: Serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

10

(2004) CST Curation Set: 394; Year: 2004; Biosample: PC3; Disease: prostate cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

11

(2004) CST Curation Set: 378; Year: 2004; SILAC: Y; Biosample1/Treatment/Isotope: BxPC-3/none/L; Biosample2/Treatment/Isotope: BxPC-3/EGF/H; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

12

(2004) CST Curation Set: 379; Year: 2004; SILAC: Y; Biosample1/Treatment/Isotope: BxPC-3/EGF/L; Biosample2/Treatment/Isotope: BxPC-3/EGF/Iressa/H; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

13

(2004) CST Curation Set: 371; Year: 2004; SILAC: Y; Biosample1/Treatment/Isotope: A431/none/L; Biosample2/Treatment/Isotope: A431/EGF/H; Disease: non-melanoma skin cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

14

(2004) CST Curation Set: 372; Year: 2004; SILAC: Y; Biosample1/Treatment/Isotope: A431/none/L; Biosample2/Treatment/Isotope: A431/EGF/H; Disease: non-melanoma skin cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

15

(2004) CST Curation Set: 368; Year: 2004; Biosample: HT-29; Disease: colorectal carcinoma; Treatment: Serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

16

(2004) CST Curation Set: 369; Year: 2004; Biosample: HT-29; Disease: colorectal carcinoma; Treatment: Serum starved & EGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

17

(2004) CST Curation Set: 370; Year: 2004; Biosample: HT-29; Disease: colorectal carcinoma; Treatment: Serum starved & IGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

18

(2004) CST Curation Set: 360; Year: 2004; Biosample: SW620; Disease: colorectal carcinoma; Treatment: Serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

19

(2004) CST Curation Set: 361; Year: 2004; Biosample: SW620; Disease: colorectal carcinoma; Treatment: Serum starved & IGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

20

(2004) CST Curation Set: 357; Year: 2004; Biosample: A431; Disease: non-melanoma skin cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

21

(2004) CST Curation Set: 358; Year: 2004; Biosample: A431; Disease: non-melanoma skin cancer; Treatment: EGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

22

(2004) CST Curation Set: 359; Year: 2004; Biosample: A431; Disease: non-melanoma skin cancer; Treatment: EGF & Iressa; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

23

(2004) CST Curation Set: 354; Year: 2004; Biosample: NCI-H1373; Disease: non-small cell lung cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

24

(2004) CST Curation Set: 400; Year: 2004; Biosample: Hs766T; Disease: pancreatic carcinoma; Treatment: Serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

25

(2004) CST Curation Set: 249; Year: 2004; Biosample: BxPC-3; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

26

(2004) CST Curation Set: 252; Year: 2004; Biosample: BxPC-3; Disease: pancreatic carcinoma; Treatment: EGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

27

(2004) CST Curation Set: 243; Year: 2004; Biosample: HPAC; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

28

(2004) CST Curation Set: 246; Year: 2004; Biosample: HPAC; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

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