Ser1360

Javascript is not enabled on this browser. This site will not work properly without Javascript.

Phosphorylation Site Page:

Site Information

VLRSPSGsQRPSVSD SwissProt Entrez-Gene

Predicted information: Scansite

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	[32P] bio-synthetic labeling (3, 4), immunoprecipitation (3), mutation of modification site (1, 2, 3), phospho-antibody (1, 3), phosphopeptide mapping (3, 4), western blotting (1, 3)
Disease tissue studied:	PA-JEB (1)
Relevant cell line - cell type - tissue:	804G (epithelial) (2), COS (fibroblast) (1, 3), COS (fibroblast) [ITGA6 (human)] (4), HaCaT (keratinocyte) (4), PA-JEB (keratinocyte) (1)

Controlled by

Downstream Regulation

Effects of modification on ITGB4:	molecular association, regulation (3)
Inhibit interaction with:	plectin 1 (human) (3)

	References

1	Frijns E, et al. (2010) EGF-induced MAPK signaling inhibits hemidesmosome formation through phosphorylation of the integrin {beta}4. J Biol Chem 285, 37650-62 20870721 Curated Info
2	Germain EC, Santos TM, Rabinovitz I (2009) Phosphorylation of a novel site on the {beta}4 integrin at the trailing edge of migrating cells promotes hemidesmosome disassembly. Mol Biol Cell 20, 56-67 19005215 Curated Info
3	Wilhelmsen K, et al. (2007) Serine phosphorylation of the integrin beta4 subunit is necessary for epidermal growth factor receptor induced hemidesmosome disruption. Mol Biol Cell 18, 3512-22 17615294 Curated Info
4	Rabinovitz I, Tsomo L, Mercurio AM (2004) Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. Mol Cell Biol 24, 4351-60 15121854 Curated Info

Home \| Curator Login	With enhanced literature mining using Linguamatics I2E		Produced by 3rd Millennium \| Design by Digizyme
			©2003-2013 Cell Signaling Technology, Inc.