Tyr992

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Phosphorylation Site Page:

Site Information

DGPLGPLyASSNPEY SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: InsR (rat): Y993, InsR (mouse): Y982, InsR iso2 (human): Y980

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	immunoprecipitation (2), mutation of modification site (2), phospho-antibody (2)
Relevant cell line - cell type - tissue:	CHO (fibroblast) [EphB1 (human), transfection] (2)

Controlled by

Kinases, in vitro:

InsR (human) (1, 2, 3)

Downstream Regulation

Effects of modification on InsR:

enzymatic activity, inhibited (1)

	References

1	Smith JE, Sheng ZF, Kallen RG (1994) Effects of tyrosine-->phenylalanine mutations on auto- and trans-phosphorylation reactions catalyzed by the insulin receptor beta-subunit cytoplasmic domain. DNA Cell Biol 13, 593-604 8024702 Curated Info
2	Murakami MS, Rosen OM (1991) The role of insulin receptor autophosphorylation in signal transduction. J Biol Chem 266, 22653-60 1658004 Curated Info
3	Tavaré JM, Denton RM (1988) Studies on the autophosphorylation of the insulin receptor from human placenta. Analysis of the sites phosphorylated by two-dimensional peptide mapping. Biochem J 252, 607-15 3166375 Curated Info

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