Tyr992
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Phosphorylation Site Page:
Tyr992 - InsR (human)

Site Information
DGPLGPLyASSNPEY    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: InsR iso2 (human): Y980, InsR (mouse): Y982, InsR (rat): Y993
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: immunoprecipitation (2), mutation of modification site (2), phospho-antibody (2)
Relevant cell line - cell type - tissue: CHO (fibroblast) [EphB1 (human), transfection] (2)

Controlled by
Kinases, in vitro: InsR (human) (1, 2, 3)

Downstream Regulation
Effects of modification on InsR: enzymatic activity, inhibited (1)


References

1

Smith JE, Sheng ZF, Kallen RG (1994) Effects of tyrosine-->phenylalanine mutations on auto- and trans-phosphorylation reactions catalyzed by the insulin receptor beta-subunit cytoplasmic domain. DNA Cell Biol 13, 593-604
8024702   Curated Info

2

Murakami MS, Rosen OM (1991) The role of insulin receptor autophosphorylation in signal transduction. J Biol Chem 266, 22653-60
1658004   Curated Info

3

Tavaré JM, Denton RM (1988) Studies on the autophosphorylation of the insulin receptor from human placenta. Analysis of the sites phosphorylated by two-dimensional peptide mapping. Biochem J 252, 607-15
3166375   Curated Info

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