Ser1333

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Phosphorylation Site Page:

Site Information

NVPLDRSsHCQREEA SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: InsR (mouse): S1323, InsR iso2 (human): S1321, InsR (rat): S1334

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	[32P] bio-synthetic labeling (1, 2), phosphoamino acid analysis (1, 2), phosphopeptide mapping (1, 2)
Relevant cell line - cell type - tissue:	3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] (2), CHO (fibroblast) [EphB1 (human), transfection] (1)

Controlled by

Regulatory protein:	PKCA (cow) (1), PKCB (cow) (1), PKCE (human) (1), PKCG (human) (1)
Treatments:	insulin (1, 2), phorbol ester (1)

Downstream Regulation

Effects of modification on InsR:

enzymatic activity, inhibited (1)

	References

1	Chin JE, Dickens M, Tavare JM, Roth RA (1993) Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling. J Biol Chem 268, 6338-47 8454604 Curated Info
2	Lewis RE, Wu GP, MacDonald RG, Czech MP (1990) Insulin-sensitive phosphorylation of serine 1293/1294 on the human insulin receptor by a tightly associated serine kinase. J Biol Chem 265, 947-54 2136851 Curated Info

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