Ser1062
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Phosphorylation Site Page:
Ser1062 - InsR (human)

Site Information
AVKTVNEsASLRERI    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: InsR (mouse): S1052, InsR iso2 (human): S1050, InsR (rat): S1063
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451562

In vivo Characterization
Methods used to characterize site in vivo: [32P] bio-synthetic labeling (3), electrophoretic mobility shift (3), immunoprecipitation (2), mutation of modification site (2, 3), phosphopeptide mapping (3), western blotting (2)
Relevant cell line - cell type - tissue: 293 (epithelial) (2), CHO (fibroblast) [EphB1 (human), transfection] (3)

Controlled by
Regulatory protein: PKCB iso2 (human) (2), PKCH (human) (2)
Kinases, in vitro: PKCA (human) (3)
Treatments: phorbol ester (3)

Downstream Regulation
Effects of modification on InsR: phosphorylation (2)


References

1

Coba MP, Turyn D, Peña C (2003) Synthesis and immunogenic properties of phosphopeptides related to the human insulin receptor. J Pept Res 61, 17-23
12472845   Curated Info

2

Strack V, et al. (2000) Serine residues 994 and 1023/25 are important for insulin receptor kinase inhibition by protein kinase C isoforms beta2 and theta. Diabetologia 43, 443-9
10819237   Curated Info

3

Liu F, Roth RA (1994) Identification of serines-1035/1037 in the kinase domain of the insulin receptor as protein kinase C alpha mediated phosphorylation sites. FEBS Lett 352, 389-92
7926007   Curated Info

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.