Ser283

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Phosphorylation Site Page:

Site Information

NLQMLPEsEDEESYD SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: IkB‑alpha (mouse): S283, IkB‑alpha (rat): S283

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	[32P] bio-synthetic labeling (3), mutation of modification site (2), phosphopeptide mapping (3), western blotting (2)
Relevant cell line - cell type - tissue:	3T3 (fibroblast) (2), Jurkat (T lymphocyte) (3)

Controlled by

Putative upstream kinases:	CK2-A1 (human) (3)
Kinases, in vitro:	CK2-A1 (human) (1, 2, 3)

Downstream Regulation

Effects of modification on IkB-alpha:

protein degradation (2)

	References

1	Shen J, Channavajhala P, Seldin DC, Sonenshein GE (2001) Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IkappaBalpha. J Immunol 167, 4919-25 11673497 Curated Info
2	Lin R, et al. (1996) Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability. Mol Cell Biol 16, 1401-9 8657113 Curated Info
3	McElhinny JA, et al. (1996) Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation. Mol Cell Biol 16, 899-906 8622692 Curated Info

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