Ser283
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Phosphorylation Site Page:
Ser283 - IkB-alpha (human)

Site Information
NLQMLPEsEDEESYD    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: IkB‑alpha (rat): S283, IkB‑alpha (mouse): S283
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: [32P] bio-synthetic labeling (3), mutation of modification site (2), phosphopeptide mapping (3), western blotting (2)
Relevant cell line - cell type - tissue: 3T3 (fibroblast) (2), Jurkat (T lymphocyte) (3)

Controlled by
Putative upstream kinases: CK2A1 (human) (3)
Kinases, in vitro: CK2A1 (human) (1, 2, 3)

Downstream Regulation
Effects of modification on IkB-alpha: protein degradation (2)


References

1

Shen J, Channavajhala P, Seldin DC, Sonenshein GE (2001) Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IkappaBalpha. J Immunol 167, 4919-25
11673497   Curated Info

2

Lin R, et al. (1996) Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability. Mol Cell Biol 16, 1401-9
8657113   Curated Info

3

McElhinny JA, et al. (1996) Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation. Mol Cell Biol 16, 899-906
8622692   Curated Info

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