Ser742
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Phosphorylation Site Page:
Ser742 - CD44 (mouse)

Site Information
LNGEASKsQEMVHLV    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: CD44 (human): S706, CD44 iso2 (mouse): S327, CD44 iso30 (human): S706, CD44 (rat): S467
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 3, 4, 5, 6, 7, 8, 9, 10, 11)
Disease tissue studied: leukemia (3), acute myelogenous leukemia (3), melanoma skin cancer (10)
Relevant cell line - cell type - tissue: 32Dcl3 (myeloid) (8), 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ~aa 525-695 ETILLNS...IFEYCC)] (8), blood (3), brain (4, 6), Hepa 1-6 (epithelial) (11), lung (6), macrophage-bone marrow (7), macrophage-bone marrow [MKP-1 (mouse), homozygous knockout] (7), MEF (fibroblast) (1, 5), MEF (fibroblast) [Raptor (mouse), knockdown] (1), MEF (fibroblast) [Rictor (mouse), knockdown] (1), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (5), RAW 267.4 (macrophage) (9), skin [mGluR1 (mouse), transgenic, TG mutant mice] (10), spleen (6)

Controlled by
Regulatory protein: Raptor (mouse) (1)
Treatments: LPS (7)



References

1

Robitaille AM, et al. (2013) Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339, 1320-3
23429704   Curated Info

2

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

3

Trost M, et al. (2012) Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, e17-27
22802335   Curated Info

4

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

5

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

6

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

7

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

8

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

9

Trost M, et al. (2009) The phagosomal proteome in interferon-gamma-activated macrophages. Immunity 30, 143-54
19144319   Curated Info

10

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

11

Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46
18846507   Curated Info

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