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Phosphorylation Site Page:
Ser742 - CD44 (mouse)

Site Information
LNGEASKsQEMVHLV    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: CD44 (human): S706, CD44 (rat): S467, CD44 iso2 (mouse): S327, CD44 iso30 (human): S706, CD44 iso12 (human): S325, CD44 iso10 (human): S457
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450988

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
Disease tissue studied: leukemia (6), acute myelogenous leukemia (6), melanoma skin cancer (13)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (2), 32Dcl3 (myeloid) (11), 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ~aa 525-695 ETILLNS...IFEYCC)] (11), blood (6), brain (7, 9), heart (3), Hepa 1-6 (epithelial) (14), lung (9), macrophage-bone marrow (10), macrophage-bone marrow [MKP-1 (mouse), homozygous knockout] (10), macrophage-peritoneum (5), macrophage-peritoneum [RIP3 (mouse), homozygous knockout] (5), MC3T3-E1 (preosteoblast) (1), MEF (fibroblast) (4, 8), MEF (fibroblast) [Raptor (mouse), knockdown] (4), MEF (fibroblast) [RICTOR (mouse), knockdown] (4), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (8), RAW 267.4 (macrophage) (12), skin [mGluR1 (mouse), transgenic, TG mutant mice] (13), spleen (9)

Controlled by
Regulatory protein: Raptor (mouse) (4)
Treatments: LPS (10)



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Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
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Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11
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Robitaille AM, et al. (2013) Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339, 1320-3
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Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
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Trost M, et al. (2012) Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, e17-27
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Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
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Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
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Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
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Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
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Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
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Trost M, et al. (2009) The phagosomal proteome in interferon-gamma-activated macrophages. Immunity 30, 143-54
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Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
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Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46
18846507   Curated Info

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