Ser187

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Phosphorylation Site Page:

Site Information

RIMEKADsNKTRIDE SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: SNAP‑25 (rat): S187, SNAP‑25 (human): S187, SNAP‑25 iso2 (human): S187

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	2D analysis (3), immunoprecipitation (4), mutation of modification site (2, 4), phospho-antibody (2, 3), western blotting (3, 4)
Relevant cell line - cell type - tissue:	'neuron, cortical'-brain (2), 'neuron, hippocampal'-brain (2, 3), chromaffin-adrenal gland (4)

Controlled by

Putative upstream kinases:	PKCA (mouse) (2, 3, 4)
Treatments:	bisindolylmaleimide (2, 4), Ca(2+) (4), depolarization (2), Go 6976 (4), kainic acid (2), KCl (4), morphine (3), naloxone (3), phorbol ester (2, 4)

Downstream Regulation

Effects of modification on SNAP-25:	inhibition (2)
Effects of modification on biological processes:	exocytosis, altered (4)

	References

1	Kataoka M, et al. (2011) A single amino acid mutation in SNAP-25 induces anxiety-related behavior in mouse. PLoS One 6, e25158 21949876 Curated Info
2	Pozzi D, et al. (2008) Activity-dependent phosphorylation of Ser187 is required for SNAP-25-negative modulation of neuronal voltage-gated calcium channels. Proc Natl Acad Sci U S A 105, 323-8 18162553 Curated Info
3	Xu NJ, et al. (2004) Inhibition of SNAP-25 phosphorylation at Ser187 is involved in chronic morphine-induced down-regulation of SNARE complex formation. J Biol Chem 279, 40601-8 15277518 Curated Info
4	Nagy G, et al. (2002) Protein kinase C-dependent phosphorylation of synaptosome-associated protein of 25 kDa at Ser187 potentiates vesicle recruitment. J Neurosci 22, 9278-86 12417653 Curated Info

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