Tyr1092

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Phosphorylation Site Page:

Tyr1092 - ALK (human)

Site Information

TSTIMTDyNPNYCFA SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: ALK (mouse): Y1096

Blast this site against: NCBI SwissProt PDB

Available spectra: 1 CST

In vivo Characterization

Methods used to characterize site in vivo:	mass spectrometry (1, 2, 3, 4, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39), mutation of modification site (40)
Disease tissue studied:	lung cancer (1, 2, 3, 4, 11, 12, 13, 17, 21), non-small cell lung cancer (1, 2, 3, 4, 11, 12, 13, 17, 21), non-small cell lung adenocarcinoma (1, 2, 3, 4, 11, 13), lymphoma (14, 18, 19, 20, 24, 26, 27, 30, 31, 34, 35, 36, 37, 38, 39), anaplastic large cell lymphoma (14, 18, 19, 20, 24, 26, 27, 30, 31, 34, 35, 36, 37, 38, 39), neuroblastoma (10)
Relevant cell line - cell type - tissue:	293T (epithelial) (16, 22, 23, 25, 28, 29, 32, 33), BaF3 ('B lymphocyte, precursor') (40), GP293 (fibroblast) [NPM-ALK (human), transfection] (9), HCC827 (pulmonary) (13), JB-6 (lymphocyte) (35), Karpas-299 (T lymphocyte) (24, 31, 38), lung (12), NCI-H2228 (pulmonary) (17), NCI-H3122 (pulmonary) (1, 2, 3, 4, 11), NCI-H838 (pulmonary) (12, 21), SMS-KCN (neural crest) (10), SR-786 (T lymphocyte) (26), SU-DHL1 (T lymphocyte) (31, 36, 37, 39), SUP-M2 (T lymphocyte) (27), TS (lymphocyte) (14, 18, 19, 20, 30, 34)

	References

1	(2011) CST Curation Set: 11907; Year: 2011; Biosample: NCI-H3122; Disease: non-small cell lung cancer; Treatment: normal; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
2	(2011) CST Curation Set: 11908; Year: 2011; Biosample: NCI-H3122; Disease: non-small cell lung cancer; Treatment: normal; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
3	(2011) CST Curation Set: 11919; Year: 2011; Biosample: NCI-H3122; Disease: non-small cell lung cancer; Treatment: normal; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
4	(2011) CST Curation Set: 11920; Year: 2011; Biosample: NCI-H3122; Disease: non-small cell lung cancer; Treatment: normal; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
5	(2010) CST Curation Set: 10551; Year: 2010; Biosample: SK-N-BE(2) TrkA CFP; Disease: neuroblastoma; Treatment: NGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
6	(2010) CST Curation Set: 10550; Year: 2010; Biosample: SK-N-BE(2) TrkA CFP; Disease: neuroblastoma; Treatment: NGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
7	(2010) CST Curation Set: 10548; Year: 2010; Biosample: SK-N-BE(2) TrkA CFP; Disease: neuroblastoma; Treatment: NGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
8	(2010) CST Curation Set: 10193; Year: 2010; Biosample: XY1-OC19; Disease: ovarian cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411 Curated Info
9	Wu F, et al. (2010) Studies of phosphoproteomic changes induced by nucleophosmin-anaplastic lymphoma kinase (ALK) highlight deregulation of tumor necrosis factor (TNF)/Fas/TNF-related apoptosis-induced ligand signaling pathway in ALK-positive anaplastic large cell lymphoma. Mol Cell Proteomics 9, 1616-32 20393185 Curated Info
10	(2008) CST Curation Set: 5181; Year: 2012; Biosample: SMS-KCN; Disease: neuroblastoma; Treatment: BDNF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
11	(2008) CST Curation Set: 4947; Year: 2008; Biosample: NCI-H3122; Disease: non-small cell lung cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
12	Rikova K, et al. (2007) Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131, 1190-203 18083107 Curated Info
13	(2007) CST Curation Set: 2874; Year: 2007; Biosample: HCC827; Disease: non-small cell lung cancer; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
14	(2006) CST Curation Set: 1306; Year: 2006; Biosample: TS; Disease: anaplastic large cell lymphoma; Treatment: A1; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
15	(2006) CST Curation Set: 1307; Year: 2006; SILAC: Y; Biosample1/Treatment/Isotope: 293T/none/L; Biosample2/Treatment/Isotope: 293T/none/H; Disease: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
16	(2006) CST Curation Set: 1308; Year: 2006; SILAC: Y; Biosample1/Treatment/Isotope: 293T/none/L; Biosample2/Treatment/Isotope: 293T/none/H; Disease: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
17	(2006) CST Curation Set: 1115; Year: 2006; Biosample: NCI-H2228; Disease: non-small cell lung cancer; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
18	(2005) CST Curation Set: 975; Year: 2005; Biosample: TS; Disease: anaplastic large cell lymphoma; Treatment: B1; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
19	(2005) CST Curation Set: 976; Year: 2005; Biosample: TS; Disease: anaplastic large cell lymphoma; Treatment: B2; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
20	(2005) CST Curation Set: 970; Year: 2005; Biosample: TS; Disease: anaplastic large cell lymphoma; Treatment: A1; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
21	(2005) CST Curation Set: 802; Year: 2005; Biosample: NCI-H838; Disease: non-small cell lung cancer; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
22	(2005) CST Curation Set: 756; Year: 2005; SILAC: Y; Biosample1/Treatment/Isotope: 293T/Tetracyclin/L; Biosample2/Treatment/Isotope: 293T/Tetracyclin/H; Disease: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
23	(2005) CST Curation Set: 677; Year: 2005; SILAC: Y; Biosample1/Treatment/Isotope: 293T/Tetracyclin/L; Biosample2/Treatment/Isotope: 293T/Tetracyclin/H; Disease: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
24	(2005) CST Curation Set: 614; Year: 2005; Biosample: Karpas-299; Disease: T cell lymphoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
25	(2005) CST Curation Set: 599; Year: 2005; SILAC: Y; Biosample1/Treatment/Isotope: 293T/Tetracyclin/L; Biosample2/Treatment/Isotope: 293T/Tetracyclin/H; Disease: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
26	(2005) CST Curation Set: 537; Year: 2005; Biosample: SR-786; Disease: T cell lymphoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
27	(2005) CST Curation Set: 538; Year: 2005; Biosample: SUP-M2; Disease: anaplastic large cell lymphoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
28	(2005) CST Curation Set: 539; Year: 2005; Biosample: 293T; Disease: -; Treatment: Tetracyclin; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
29	(2005) CST Curation Set: 540; Year: 2005; Biosample: 293T; Disease: -; Treatment: Tetracyclin; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
30	(2005) CST Curation Set: 529; Year: 2005; Biosample: TS; Disease: anaplastic large cell lymphoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
31	Rush J, et al. (2005) Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat Biotechnol 23, 94-101 15592455 Curated Info
32	(2004) CST Curation Set: 507; Year: 2004; Biosample: 293T; Disease: -; Treatment: serum starved; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
33	(2004) CST Curation Set: 508; Year: 2004; Biosample: 293T; Disease: -; Treatment: serum starved & Tetracyclin; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
34	(2004) CST Curation Set: 484; Year: 2004; Biosample: TS; Disease: anaplastic large cell lymphoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
35	(2004) CST Curation Set: 483; Year: 2004; Biosample: JB-6; Disease: anaplastic large cell lymphoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
36	(2004) CST Curation Set: 398; Year: 2004; Biosample: SU-DHL1; Disease: anaplastic large cell lymphoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
37	(2003) CST Curation Set: 224; Year: 2003; Biosample: SU-DHL1; Disease: anaplastic large cell lymphoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-y(phosphorylation) Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
38	(2003) CST Curation Set: 178; Year: 2003; Biosample: Karpas-299; Disease: T cell lymphoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
39	(2003) CST Curation Set: 181; Year: 2003; Biosample: SU-DHL1; Disease: anaplastic large cell lymphoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
40	Bai RY, et al. (2000) Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway. Blood 96, 4319-27 11110708 Curated Info

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