Tyr1178

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Phosphorylation Site Page:

Tyr1178 - InsR iso2 (human)

Site Information

DIYETDYyRKGGKGL SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: InsR (human): Y1190, InsR (mouse): Y1180, InsR (rat): Y1191

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	[32P] bio-synthetic labeling (5), mass spectrometry (1, 2, 3, 4), peptide sequencing (5), phospho-antibody (5), phosphoamino acid analysis (5)
Disease tissue studied:	colorectal cancer (4), colorectal carcinoma (4), lung cancer (3), non-small cell lung cancer (3)
Relevant cell line - cell type - tissue:	3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] (5), CHO (fibroblast) [EphB1 (human), transfection] (5), HT-29 (intestinal) (4), lung (3), NCI-H1703 (squamous) (3), NCI-H2228 (pulmonary) (1, 2)

Controlled by

Kinases, in vitro:	InsR (human) (5)
Treatments:	insulin (5)

	References

1	(2008) CST Curation Set: 5327; Year: 2008; Biosample: NCI-H2228; Disease: non-small cell lung adenocarcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
2	(2008) CST Curation Set: 5328; Year: 2008; Biosample: NCI-H2228; Disease: non-small cell lung adenocarcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
3	Rikova K, et al. (2007) Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131, 1190-203 18083107 Curated Info
4	(2004) CST Curation Set: 370; Year: 2004; Biosample: HT-29; Disease: colorectal carcinoma; Treatment: Serum starved & IGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
5	Tennagels N, et al. (2001) Identification of Ser(1275) and Ser(1309) as autophosphorylation sites of the human insulin receptor in intact cells. Biochem Biophys Res Commun 282, 387-93 11401470 Curated Info

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