Tyr1173

Javascript is not enabled on this browser. This site will not work properly without Javascript.

Home

Phosphorylation Site Page:

Tyr1173 - InsR iso2 (human)

Site Information

FGMTRDIyETDYYRK SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: InsR (human): Y1185, InsR (rat): Y1186, InsR (mouse): Y1175

Blast this site against: NCBI SwissProt PDB

Available spectra: 1 CST

In vivo Characterization

Methods used to characterize site in vivo:	[32P] bio-synthetic labeling (7), mass spectrometry (1, 2, 3, 4, 5, 6), peptide sequencing (7), phospho-antibody (7), phosphoamino acid analysis (7)
Disease tissue studied:	colorectal cancer (6), colorectal carcinoma (6), gastric cancer (3), gastric carcinoma (3)
Relevant cell line - cell type - tissue:	3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] (7), CHO (fibroblast) [EphB1 (human), transfection] (7), HT-29 (intestinal) (6), MKN-45 (gastric) (3), NCI-H2228 (pulmonary) (1, 2), SW480 (intestinal) (5)

Controlled by

Kinases, in vitro:	InsR (human) (7)
Treatments:	insulin (7)

	References

1	(2008) CST Curation Set: 5327; Year: 2008; Biosample: NCI-H2228; Disease: non-small cell lung adenocarcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
2	(2008) CST Curation Set: 5328; Year: 2008; Biosample: NCI-H2228; Disease: non-small cell lung adenocarcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
3	Guo A, et al. (2008) Signaling networks assembled by oncogenic EGFR and c-Met. Proc Natl Acad Sci U S A 105, 692-7 18180459 Curated Info
4	(2006) CST Curation Set: 2053; Year: 2006; Biosample: ENT01; Disease: laryngeal cancer; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
5	(2005) CST Curation Set: 573; Year: 2005; Biosample: SW480; Disease: colorectal carcinoma; Treatment: IGF1; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
6	(2004) CST Curation Set: 370; Year: 2004; Biosample: HT-29; Disease: colorectal carcinoma; Treatment: Serum starved & IGF; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
7	Tennagels N, et al. (2001) Identification of Ser(1275) and Ser(1309) as autophosphorylation sites of the human insulin receptor in intact cells. Biochem Biophys Res Commun 282, 387-93 11401470 Curated Info

Home \| Curator Login	With enhanced literature mining using Linguamatics I2E		Produced by 3rd Millennium \| Design by Digizyme
			©2003-2013 Cell Signaling Technology, Inc.