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Phosphorylation Site Page:
Ser105 - Tau iso3 (human)

Site Information
GDRSGYssPGsPGTP   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: Tau (mouse): S491, Tau (rat): S510, Tau iso8 (human): S199, Tau iso2 (human): (S141), Tau iso6 (human): (S141), Tau (cow): (S206), Tau iso5 (human): S199, Tau (human): S516, Tau iso3 (mouse): (S188), Tau iso7 (mouse): (S148), Tau iso7 (human): (S170)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447927

In vivo Characterization
Methods used to characterize site in vivo: mutation of modification site (1)
Disease tissue studied: adrenal cancer (1), pheochromocytoma (1)
Relevant cell line - cell type - tissue: PC-12 (chromaffin) (1)

Controlled by
Treatments: okadaic_acid (1)

Downstream Regulation
Effects of modification on Tau iso3: molecular association, regulation (1)
Effects of modification on biological processes: cytoskeletal reorganization (1)



Maas T, Eidenm├╝ller J, Brandt R (2000) Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments. J Biol Chem 275, 15733-40
10747907   Curated Info

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