Thr1207
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Phosphorylation Site Page:
Thr1207 - SCC-112 (mouse)

Site Information
PVRIISVtPVKNIDT   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: SCC‑112 (human): T1208, SCC‑112 (rat): T1207
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 453749

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (2, 3, 4, 5, 6)
Disease tissue studied: brain cancer (4), neuroendocrine cancer (4)
Relevant cell line - cell type - tissue: 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ~aa 525-695 ETILLNS...IFEYCC)] (6), brain (4), liver (3), liver [leptin (mouse), homozygous knockout] (3), macrophage-peritoneum (2), macrophage-peritoneum [RIP3 (mouse), homozygous knockout] (2), MEF (fibroblast) [p53 (mouse), homozygous knockout] (5)

Controlled by
Regulatory protein: RIP3 (mouse) (2)



References

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

3

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

4

Guo A (2011) CST Curation Set: 12730; Year: 2011; Biosample/Treatment: tissue, brain/untreated; Disease: brain cancer; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-(s/t)P(phosphorylation)
Curated Info

5

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

6

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.