Thr1207
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Phosphorylation Site Page:
Thr1207 - SCC-112 (mouse)

Site Information
PVRIISVtPVKNIDT   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: SCC‑112 (human): T1208, SCC‑112 (rat): T1207
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 453749

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5)
Disease tissue studied: brain cancer (3), neuroendocrine cancer (3)
Relevant cell line - cell type - tissue: 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ~aa 525-695 ETILLNS...IFEYCC)] (5), brain (3), liver (2), liver [leptin (mouse), homozygous knockout] (2), macrophage-peritoneum (1), macrophage-peritoneum [RIP3 (mouse), homozygous knockout] (1), MEF (fibroblast) [p53 (mouse), homozygous knockout] (4)

Controlled by
Regulatory protein: RIP3 (mouse) (1)



References

1

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

2

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

3

(2011) CST Curation Set: 12730; Year: 2011; Biosample/Treatment: tissue, brain/untreated; Disease: brain cancer; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-(s/t)P(phosphorylation)
Curated Info

4

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

5

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

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