Ser599
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Phosphorylation Site Page:
Ser599 - JMJD1B (mouse)

Site Information
FEAVKRFsLDERSLA   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: JMJD1B (human): S798, JMJD1B iso3 (mouse): (S799), JMJD1B iso2 (human): (S454)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471053

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 3, 4, 5, 6, 7)
Disease tissue studied: leukemia (4), acute myelogenous leukemia (4), melanoma skin cancer (7)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (1, 3), 32Dcl3 (myeloid) (6), 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ~aa 525-695 ETILLNS...IFEYCC)] (6), blood (4), macrophage-bone marrow (5), macrophage-bone marrow [MKP-1 (mouse), homozygous knockout] (5), skin [mGluR1 (mouse), transgenic, TG mutant mice] (7)

Controlled by
Treatments: insulin (3), LPS (5)



References

1

Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6
26060331   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

4

Trost M, et al. (2012) Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, e17-27
22802335   Curated Info

5

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

6

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

7

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

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