Ser599
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Phosphorylation Site Page:
Ser599 - JMJD1B (mouse)

Site Information
FEAVKRFsLDERSLA   SwissProt Entrez-Gene
Predicted information:  Scansite
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471053

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 5, 6, 7, 8, 9)
Disease tissue studied: leukemia (6), acute myelogenous leukemia (6), melanoma skin cancer (9)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (1, 2, 5), 32Dcl3 (myeloid) (8), 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ~aa 525-695 ETILLNS...IFEYCC)] (8), blood (6), macrophage-bone marrow (7), macrophage-bone marrow [DUSP1 (mouse), homozygous knockout] (7), RAW 264.7 (macrophage) (3), skin [mGluR1 (mouse), transgenic, TG mutant mice] (9)

Controlled by
Treatments: IL-33 (3), insulin (5), LPS (7)



References

1

Minard AY, et al. (2016) mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes. Cell Rep 17, 29-36
27681418   Curated Info

2

Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6
26060331   Curated Info

3

Pinto SM, et al. (2015) Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532-44
25367039   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

6

Trost M, et al. (2012) Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, e17-27
22802335   Curated Info

7

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

8

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

9

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

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