Ser458
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Phosphorylation Site Page:
Ser458 - CD44 (rat)

Site Information
TVEDRKPsELNGEAS   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: CD44 (human): S697, CD44 (mouse): S733, CD44 iso10 (human): (S448), CD44 iso12 (human): (S316), CD44 iso30 (human): (S697), CD44 iso2 (mouse): (S318)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 465669

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4)
Disease tissue studied: adrenal cancer (3, 4), pheochromocytoma (3, 4)
Relevant cell line - cell type - tissue: IEC-6 (epithelial) (1), lung (2), PC-12 (chromaffin) (3, 4), stomach (2)

Controlled by
Treatments: serum (1)



References

1

Courcelles M, et al. (2013) Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions. Mol Syst Biol 9, 669
23712012   Curated Info

2

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

3

(2009) CST Curation Set: 6823; Year: 2009; Biosample/Treatment: cell line, PC-12/forskolin; Disease: pheochromocytoma; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-RRX(s/t)(phosphorylation) Antibody Used to Purify Peptides prior to MS2: Phospho-PKA Substrate (RRXS/T) (100G7) Rabbit mAb Cat#: 9624, PTMScan(R) Phospho-PKA Substrate Motif (K/RK/RXS*/T*) Immunoaffinity Beads Cat#: 1984
Curated Info

4

(2009) CST Curation Set: 6821; Year: 2009; Biosample/Treatment: cell line, PC-12/forskolin; Disease: pheochromocytoma; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-RRX(s/t)(phosphorylation) Antibody Used to Purify Peptides prior to MS2: Phospho-PKA Substrate (RRXS/T) (100G7) Rabbit mAb Cat#: 9624, PTMScan(R) Phospho-PKA Substrate Motif (K/RK/RXS*/T*) Immunoaffinity Beads Cat#: 1984
Curated Info

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