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Phosphorylation Site Page:
Ser290 - CREM iso3 (mouse)

Site Information
AsPGSLHsPQQLAEE   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: CREM (human): S293, CREM iso2 (mouse): (S178), CREM iso2 (human): (S169), CREM (mouse): S178, CREM iso3 (human): (S281), CREM iso8 (human): (S53)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450066

In vivo Characterization
Methods used to characterize site in vivo: [32P] bio-synthetic labeling (1, 2), mutation of modification site (1), phosphoamino acid analysis (1, 2), phosphopeptide mapping (1, 2)
Relevant cell line - cell type - tissue: COS (fibroblast) (1, 2)

Controlled by
Putative upstream kinases: CDK1 (mouse) (1)
Kinases, in vitro: CDK1 (mouse) (1, 2)

Downstream Regulation
Effects of modification on CREM iso3: activity, inhibited (1)
Effects of modification on biological processes: transcription, altered (1)



de Groot RP, Derua R, Goris J, Sassone-Corsi P (1993) Phosphorylation and negative regulation of the transcriptional activator CREM by p34cdc2. Mol Endocrinol 7, 1495-50
8114763   Curated Info


de Groot RP, et al. (1993) Multiple and cooperative phosphorylation events regulate the CREM activator function. EMBO J 12, 3903-11
8404858   Curated Info

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