Ser746
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Phosphorylation Site Page:
Ser746 - Kit (human)

Site Information
RRSVRIGsYIERDVT   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: Kit (mouse): S748, Kit (rat): S747
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450036

In vivo Characterization
Methods used to characterize site in vivo: [32P] bio-synthetic labeling (2), mutation of modification site (2), phospho-antibody (1), phosphoamino acid analysis (2)
Relevant cell line - cell type - tissue: COS (fibroblast) (1), hematopoietic progenitor-bone marrow (1), PAE (endothelial) (2)

Controlled by
Kinases, in vitro: PKCA (human) (2)
Treatments: Ro31-8220 (1), SCF (1, 2)

Downstream Regulation
Effects of modification on Kit: enzymatic activity, inhibited (2), phosphorylation (2)


References

1

Edling CE, et al. (2007) Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation. Br J Haematol 136, 260-8
17156394   Curated Info

2

Blume-Jensen P, Wernstedt C, Heldin CH, Rönnstrand L (1995) Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells. J Biol Chem 270, 14192-200
7539802   Curated Info

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.