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Phosphorylation Site Page:
Ser746 - Kit (human)

Site Information
RRSVRIGsYIERDVT   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: Kit (mouse): S748, Kit (rat): S747
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450036

In vivo Characterization
Methods used to characterize site in vivo: [32P] bio-synthetic labeling (2), mutation of modification site (2), phospho-antibody (1), phosphoamino acid analysis (2)
Relevant cell line - cell type - tissue: COS (fibroblast) (1), hematopoietic progenitor-bone marrow (1), PAE (endothelial) (2)

Controlled by
Kinases, in vitro: PKCA (human) (2)
Treatments: Ro31-8220 (1), SCF (1, 2)

Downstream Regulation
Effects of modification on Kit: enzymatic activity, inhibited (2), phosphorylation (2)



Edling CE, et al. (2007) Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation. Br J Haematol 136, 260-8
17156394   Curated Info


Blume-Jensen P, Wernstedt C, Heldin CH, Rönnstrand L (1995) Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells. J Biol Chem 270, 14192-200
7539802   Curated Info

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