Ser503
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Phosphorylation Site Page:
Ser503 - CEACAM1 (rat)

Site Information
QQSKRPTsASSSPTE   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: CEACAM1 (human): S508, CEACAM1 (mouse): S503, CEACAM1 iso9 (human): (‑), CEACAM1 iso8 (human): (‑)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448536

In vivo Characterization
Methods used to characterize site in vivo: [32P] bio-synthetic labeling (3, 4), electrophoretic mobility shift (2), immunoprecipitation (2, 4), mutation of modification site (1, 2, 3, 4), phospho-antibody (2), phosphoamino acid analysis (4), western blotting (3)
Relevant cell line - cell type - tissue: 3T3 (fibroblast) (3), 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] (2), COS (fibroblast) (4), hepatocyte (1), hepatocyte-liver (2), liver (1)

Controlled by
Putative upstream kinases: PKCA (rat) (4)
Treatments: insulin (3), phorbol ester (4), staurosporine (4)

Downstream Regulation
Effects of modification on CEACAM1: activity, induced (1, 3, 4), intracellular localization (2), receptor internalization, altered (1)


References

1

Poy MN, et al. (2002) CEACAM1 regulates insulin clearance in liver. Nat Genet 30, 270-6
11850617   Curated Info

2

Choice CV, Poy MN, Formisano P, Najjar SM (1999) Comparison of the intracellular trafficking of two alternatively spliced isoforms of pp120, a substrate of the insulin receptor tyrosine kinase. J Cell Biochem 76, 133-42
10581007   Curated Info

3

Najjar SM, et al. (1995) Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase. Biochemistry 34, 9341-9
7626603   Curated Info

4

Sippel CJ, Fallon RJ, Perlmutter DH (1994) Bile acid efflux mediated by the rat liver canalicular bile acid transport/ecto-ATPase protein requires serine 503 phosphorylation and is regulated by tyrosine 488 phosphorylation. J Biol Chem 269, 19539-45
7518458   Curated Info

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.