Thr551
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Phosphorylation Site Page:
Thr551 - CTNNB1 (mouse)

Site Information
HQDTQRRtSMGGTQQ   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: CTNNB1 (human): T551, CTNNB1 (rat): T551
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 486050

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7)
Disease tissue studied: anthrax infection (3), melanoma skin cancer (6)
Relevant cell line - cell type - tissue: 'brain, cerebral cortex' (5, 7), liver (1), liver [leptin (mouse), homozygous knockout] (1), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (2), mpkCCD (renal) (4), skin [mGluR1 (mouse), transgenic, TG mutant mice] (6), spleen (3)




References

1

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

2

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

3

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

4

Rinschen MM, et al. (2010) Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Proc Natl Acad Sci U S A 107, 3882-7
20139300   Curated Info

5

Tweedie-Cullen RY, Reck JM, Mansuy IM (2009) Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain. J Proteome Res 8, 4966-82
19737024   Curated Info

6

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

7

Munton RP, et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics 6, 283-93
17114649   Curated Info

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